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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
STEVOR is a plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting
Cell Host and Microbe, Volume 16, No. 1, Year 2014
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Description
Variant surface antigens play an important role in Plasmodium falciparum malaria pathogenesis and in immune evasion by the parasite. Although most work to date has focused on P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are expressed in invasive merozoites and on the infected erythrocyte surface. However, their role during parasite infection remains to be clarified. Here we report that STEVOR functions as an erythrocyte-binding protein that recognizes Glycophorin C (GPC) on the red blood cell (RBC) surface and that its binding correlates with the level of GPC on the RBC surface. STEVOR expression on the RBC leads to PfEMP1-independent binding of infected RBCs to uninfected RBCs (rosette formation), while antibodies targeting STEVOR in the merozoite can effectively inhibit invasion. Our results suggest a PfEMP1-independent role for STEVOR in enabling infected erythrocytes at the schizont stage to form rosettes and in promoting merozoite invasion. © 2014 Elsevier Inc.
Authors & Co-Authors
Niang, Makhtar S.
Singapore, Singapore City
School of Biological Sciences
Senegal, Dakar
Institut Pasteur de Dakar
Bei, Amy Kristine
United States, Boston
Harvard T.h. Chan School of Public Health
Madnani, Kripa Gopal
Singapore, Singapore City
School of Biological Sciences
Pelly, Shaaretha
Singapore, Singapore City
School of Biological Sciences
Dankwa, Selasi
United States, Boston
Harvard T.h. Chan School of Public Health
Kanjee, Usheer
United States, Boston
Harvard T.h. Chan School of Public Health
Gunalan, Karthigayan
Singapore, Singapore City
School of Biological Sciences
Amaladoss, Anburaj
Singapore, Singapore City
Singapore-mit Alliance for Research and Technology
Yeo, Kim Pin
Singapore, Singapore City
School of Biological Sciences
Bob, Ndeye Sakha
Singapore, Singapore City
School of Biological Sciences
Malleret, B.
Singapore, Singapore City
Nus Yong Loo Lin School of Medicine
Singapore, Singapore City
A-star, Singapore Immunology Network
Duraisingh, Manoj Theodore
United States, Boston
Harvard T.h. Chan School of Public Health
Preiser, Peter R.
Singapore, Singapore City
School of Biological Sciences
Statistics
Citations: 167
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1016/j.chom.2014.06.004
ISSN:
19313128
e-ISSN:
19346069
Research Areas
Infectious Diseases