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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of maternal HIV status on infant mortality: Evidence from a 9-month follow-up of mothers and their infants in Zimbabwe
Journal of Perinatology, Volume 30, No. 2, Year 2010
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Description
Objective: To describe infant mortality trends and associated factors among infants born to mothers enrolled in a prevention of mother-to-child transmission (PMTCT) program. Study Design: A nested case-control study of human immunodeficiency virus (HIV)-positive and-negative pregnant women enrolled from the national PMTCT program at 36 weeks of gestation attending three peri-urban clinics in Zimbabwe offering maternal and child health care. Mother-infant pairs were followed up from delivery, and at 6 weeks, 4 months and 9 months. Results: A total of 1045 mother and singleton infant pairs, 474 HIV-positive and 571 HIV-negative mothers, delivered 469 and 569 live infants, respectively. Differences in mortality were at 6 weeks and 4 months, RR (95% CI) 9.71 (1.22 to 77.32) and 21.84 (2.93 to 162.98), respectively. Overall, 9-month mortality rates were 150 and 47 per 1000 person-years for infants born to HIV-positive and HIV-negative mothers, respectively. Proportional hazard ratio of mortality for children born to HIV-positive mothers was 3.21 (1.91 to 5.38) when compared with that for children born to HIV-negative mothers. Conclusion: Maternal HIV exposure was associated with higher mortality in the first 4 months of life. Infant's HIV status was the strongest predictor of infant mortality. There is a need to screen infants for HIV from delivery and throughout breastfeeding. © 2010 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Kurewa, Edith Nyaradzai
Zimbabwe, Harare
University of Zimbabwe
Norway, Oslo
Medisinske Fakultet
Gumbo, Felicity Zvanyadza
Zimbabwe, Harare
University of Zimbabwe
Munjoma, Marshall Wesley
Zimbabwe, Harare
University of Zimbabwe
Mapingure, Munyaradzi Paul
Norway, Oslo
Medisinske Fakultet
Chirenje, Mike Zvavahera
Zimbabwe, Harare
University of Zimbabwe
Rusakaniko, Simbarashe
Zimbabwe, Harare
University of Zimbabwe
Stray-Pedersen, Babill
Norway, Oslo
Universitetet I Oslo
Statistics
Citations: 47
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1038/jp.2009.121
ISSN:
07438346
e-ISSN:
14765543
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Study Locations
Zimbabwe
Participants Gender
Female