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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
Journal of Experimental Medicine, Volume 207, No. 2, Year 2010
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Description
Most patients with autoimmune polyendocrine syndrome type I (APS-I) display chronic mucocutaneous candidiasis (CMC). We hypothesized that this CMC might result from autoimmunity to interleukin (IL)-17 cytokines. We found high titers of autoantibodies (auto-Abs) against IL-17A, IL-17F, and/or IL-22 in the sera of all 33 patients tested, as detected by multiplex particle-based flow cytometry. The auto-Abs against IL-17A, IL-17F, and IL-22 were specific in the five patients tested, as shown by Western blotting. The auto-Abs against IL-17A were neutralizing in the only patient tested, as shown by bioassays of IL-17A activity. None of the 37 healthy controls and none of the 103 patients with other autoimmune disorders tested had such auto-Abs. None of the patients with APS-I had auto-Abs against cytokines previously shown to cause other welldefined clinical syndromes in other patients (IL-6, interferon [IFN]-γ, or granulocyte/macrophage colony-stimulating factor) or against other cytokines (IL-1β, IL-10, IL-12, IL-18, IL-21, IL-23, IL-26, IFN-β, tumor necrosis factor [α], or transforming growth factor β). These findings suggest that auto-Abs against IL-17A, IL-17F, and IL-22 may cause CMC in patients with APS-I. © 2010 Puel et al.
Authors & Co-Authors
Puel, Anne
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Döffinger, Rainer
United Kingdom, Cambridge
Addenbrooke's Hospital
Natividad, Angels
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Chrabieh, Maya
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Barcenas-Morales, Gabriela
Mexico, Cuautitlan Izcalli
Facultad de Estudios Superiores Cuautitlán
Pïcard, Capucine
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Cobat, Aurélie
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Ouachée-Chardin, Marie
France, Paris
Hôpital Robert-debré Ap-hp
Toulon, Antoine
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Bustamante, Jacinta Cecilia
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Al-Muhsen, Saleh Zaid
Saudi Arabia, Riyadh
College of Medicine
Al-Owain, Mohammed Abdulaziz
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Arkwright, Peter D.
United Kingdom, Manchester
The University of Manchester
Costigan, Colm
Ireland, Dublin
Our Lady's Hospital for Sick Children
McConnell, Vivienne
United Kingdom, Belfast
Belfast City Hospital
Cant, Andrew James
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Abinun, Mario A.
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Polak, Michel
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Bougnères, Pierre François
France, Paris
Hopital Saint-vincent-de-paul
Kumararatne, Dinakantha S.
United Kingdom, Cambridge
Addenbrooke's Hospital
Máródi, László D.R.
Hungary, Debrecen
Általános Orvostudományi Kar
Nahum, Amit
Canada, Toronto
Hospital for Sick Children University of Toronto
Roifman, Chaim M.
Canada, Toronto
Hospital for Sick Children University of Toronto
Blanche, Stéphane
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Fischer, Alain M.
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
France, Paris
Inserm
Bodemer, Christine
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Abel, Laurent
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Lilic, Desa
United Kingdom, Newcastle
Newcastle University
Casanova, Jean Laurent
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
United States, New York
Rockefeller University
Statistics
Citations: 80
Authors: 29
Affiliations: 18
Identifiers
Doi:
10.1084/jem.20091983
ISSN:
00221007
e-ISSN:
15409538
Research Areas
Cancer
Health System And Policy