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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Haptoglobin phenotypes and iron status in children living in a malaria endemic area of Kenyan coast
Acta Tropica, Volume 126, No. 2, Year 2013
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Description
Malaria infection may be affected by host genetic factors as well as nutritional status. Iron status and the phenotype of haptoglobin, a heme-binding acute phase reactant may be determinants of malaria parasitemia. A combination of cross sectional studies and longitudinal follow-up were used to describe the association between iron status, C-reactive protein, malaria infections and host genetic factors including; haptoglobin (Hp) phenotypes, in children below 9 years in a malaria endemic area in Coastal Kenya. The prevalence of 0.45 and 0.41, respectively for Hp 1-1 and Hp 2-1 phenotypes was significantly higher than 0.14 for Hp 2-2 phenotype (n=162). Children with Hp 2-2 phenotype showed significantly higher iron storage compared to those with Hp 1-1 and Hp 2-1 phenotypes when children with malaria parasites and high C-reactive protein (>9. mg/L) were excluded from the analysis. There were no significant differences in malaria parasite densities among Hp phenotypes but children with Hp 2-2 had lower number of clinical malaria episodes (P=0.045). Taken together, this study shows that the presence of malaria may complicate the interpretation of iron status in children based on their Hp-phenotypes. Further studies will be required to address possible interactions among the various genetic factors and iron status in a malaria endemic setting. © 2013.
Authors & Co-Authors
Nyakeriga, Alice M.
United States, El Paso
Texas Tech University Health Sciences Center el Paso
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Troye-Blomberg, Marita
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
Statistics
Citations: 8
Authors: 2
Affiliations: 3
Identifiers
Doi:
10.1016/j.actatropica.2013.02.004
ISSN:
0001706X
e-ISSN:
18736254
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Kenya