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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Some new biologically active metal-based sulfonamide
European Journal of Medicinal Chemistry, Volume 45, No. 7, Year 2010
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Description
A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, 1H and 13C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methylidene]amino}-N-(4,6-dimethylpyrimidin-2- yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains. © 2010 Elsevier Masson SAS.
Authors & Co-Authors
Chohan, Zahid Hussain
Pakistan, Multan
Bahauddin Zakariya University
Shad, Hazoor Ahmad
Pakistan, Multan
Bahauddin Zakariya University
Youssoufi, Moulay Hfid
Morocco, Oujda
Université Mohammed Premier Oujda
Ben Hadda, Taibi
Morocco, Oujda
Université Mohammed Premier Oujda
Statistics
Citations: 63
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejmech.2010.03.014
ISSN:
02235234
e-ISSN:
17683254