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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Time to undetectable viral load after highly active antiretroviral therapy initiation among HIV-infected pregnant women
Clinical Infectious Diseases, Volume 44, No. 12, Year 2007
Notification
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Description
Background. There have been no clinical trials in resource-rich regions that have addressed the question of which highly active antiretroviral therapy (HAART) regimens are more effective for optimal viral response in antiretroviral-naive, human immunodeficiency virus (HIV)-infected pregnant women. Methods. Data on 240 HIV-1-infected women starting HAART during pregnancy who were enrolled in the prospective European Collaborative Study from 1997 through 2004 were analyzed. An interval-censored survival model was used to assess whether factors, including type of HAART regimen, race, region of birth, and baseline immunological and virological status, were associated with the duration of time necessary to suppress viral load below undetectable levels before delivery of a newborn. Results. Protease inhibitor-based HAART was initiated in 156 women (65%), 125 (80%) of whom received nelfinavir, and a nevirapine-based regimen was initiated in the remaining 84 women (35%). Undetectable viral loads were achieved by 73% of the women by the time of delivery. Relative hazards of time to achieving viral suppression were 1.54 (95% confidence interval, 1.05-2.26) for nevirapine-based HAART versus PI-based regimens and 1.90 (95% confidence interval, 1.16-3.12) for western African versus non-African women. The median duration of time from HAART initiation to achievement of an undetectable viral load was estimated to be 1.4 times greater in women receiving PI-based HAART, compared with women receiving nevirapine-based HAART. Baseline HIV RNA load was also a significant predictor of the rapidity of achieving viral suppression by delivery, but baseline immune status was not. Conclusions. In this study, nevirapine-based HAART (compared with PI [mainly nelfinavir]-based HAART), western African origin, and lower baseline viral load were associated with shorter time to achieving viral suppression. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Patel, Deven V.
United Kingdom, London
University College London
Cortina-Borja, Mario J.F.
United Kingdom, London
University College London
Thorne, Claire N.
United Kingdom, London
University College London
Newell, Marie Louise
United Kingdom, London
University College London
Giaquinto, Carlo
Italy, Padua
Università Degli Studi Di Padova
D'Elia, Ruggiero D.
Italy, Padua
Università Degli Studi Di Padova
De Rossi, Anita
Italy, Padua
Università Degli Studi Di Padova
Grosch-Wörner, Ilse
Germany, Berlin
Charité – Universitätsmedizin Berlin
Mok, Jacqueline Y.Q.
United Kingdom, Edinburgh
Royal Hospital for Sick Children
Bates, Isabel
Spain, Madrid
Hospital Materno-infantil
González-García, Juan Julián
Spain, Madrid
Hospital Materno-infantil
Arribas, Jose R.
Spain, Madrid
Hospital Materno-infantil
García Rodriguez, Marie Cruz
Spain, Madrid
Hospital Materno-infantil
Asensi-Botet, Francesc
Spain, Valencia
Hospital Universitari I Politècnic la fe
Otero, Ma Carmen
Spain, Valencia
Hospital Universitari I Politècnic la fe
Scherpbier, Henriëtte J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Boer, Kees R.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Bohlin, Ann Britt
Sweden, Stockholm
Karolinska Universitetssjukhuset
Lindgren, Susanne Rosa
Sweden, Stockholm
Karolinska Universitetssjukhuset
Anzèn, Bo
Sweden, Stockholm
Karolinska Universitetssjukhuset
Lidman, Knut
Sweden, Stockholm
Karolinska Universitetssjukhuset
Pehrson, Pehrolov
Sweden, Stockholm
Karolinska Universitetssjukhuset
Lévy, Jack A.
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Barlow, Patricia
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Hainaut, Marc
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Peltier, Alexandra
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Goetghebuer, Tessa
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Ferrazin, Antonio
Italy, Genoa
Università Degli Studi Di Genova
de Maria, Andrea F.
Italy, Genoa
Università Degli Studi Di Genova
Gotta, Cristina
Italy, Genoa
Università Degli Studi Di Genova
Mur-Sierra, Antonío
Spain, Barcelona
Hospital Del Mar
Paya, A.
Spain, Barcelona
Hospital Del Mar
Carreras, Ramón C.
Spain, Barcelona
Hospital Del Mar
Coll, Oriol
Spain, Barcelona
Hospital Clinic Barcelona
Fortuny, Clàudia
Spain, Esplugues de Llobregat
Hospital Sant Joan de Déu Barcelona
Boguñà, Josep Maria
Spain, Esplugues de Llobregat
Hospital Sant Joan de Déu Barcelona
Casellas-Caro, Manuel
Spain, Barcelona
Hospital Universitari Vall D'hebron
Canet, Yolanda
Spain, Sabadell
Hospital de Sabadell
Pardi, Giorgio
Italy, Milan
Ospedale San Paolo
Lanari, Marcello
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Duse, Marzia
Italy, Brescia
Università Degli Studi Di Brescia
Savasi, Valeria Maria
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Fiore, Simona
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Ferrazzi, Enrico Maria
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Giacomet, Vania
Italy, Milan
Università Degli Studi Di Milano
Zuccotti, Gianvincenzo Vincenzo
Italy, Milan
Università Degli Studi Di Milano
Taylor, Graham P.
United Kingdom, London
St Mary's Hospital
Martinelli, Pasquale
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Tibaldi, Cecilia
Italy, Turin
Università Degli Studi Di Torino
Benedetto, Chiara
Italy, Turin
Università Degli Studi Di Torino
Niemieç, Tomasz
Poland, Warsaw
Instytut Matki I Dziecka
Marczyńska, Magdalena
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Popielska, Jolanta
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Malyuta, Ruslan
Unknown Affiliation
Semenenko, Igor
Unknown Affiliation
Posokhova, Svetlana
Unknown Affiliation
Stelmah, Andrej
Unknown Affiliation
Statistics
Citations: 125
Authors: 57
Affiliations: 32
Identifiers
Doi:
10.1086/518284
ISSN:
10584838
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female