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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rationale and design of the comparison of 3 combination therapies in lowering blood pressure in black Africans (CREOLE study): 2 × 3 factorial randomized single-blind multicenter trial
American Heart Journal, Volume 202, Year 2018
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Description
Background: Current hypertension guidelines recommend the use of combination therapy as first-line treatment or early in the management of hypertensive patients. Although there are many possible combinations of blood pressure(BP)–lowering therapies, the best combination for the black population is still a subject of debate because no large randomized controlled trials have been conducted in this group to compare the efficacy of different combination therapies to address this issue. Methods: The comparison of 3 combination therapies in lowering BP in the black Africans (CREOLE) study is a randomized single-blind trial that will compare the efficacy of amlodipine plus hydrochlorothiazide versus amlodipine plus perindopril and versus perindopril plus hydrochlorothiazide in blacks residing in sub-Saharan Africa (SSA). Seven hundred two patients aged 30-79 years with a sitting systolic BP of 140 mm Hg and above, and less than 160 mm Hg on antihypertensive monotherapy, or sitting systolic BP of 150 mm Hg and above, and less than 180 mm Hg on no treatment, will be centrally randomized into any of the 3 arms (234 into each arm). The CREOLE study is taking place in 10 sites in SSA, and the primary outcome measure is change in ambulatory systolic BP from baseline to 6 months. The first patient was randomized in June 2017, and the trial will be concluded by 2019. Conclusions: The CREOLE trial will provide unique information as to the most efficacious 2-drug combination in blacks residing in SSA and thereby inform the development of clinical guidelines for the treatment of hypertension in this subregion. © 2018
Authors & Co-Authors
Ojji, Dike Brevis
Nigeria, Abuja
University of Abuja
Poulter, Neil R.
United Kingdom, London
Imperial College London
Damasceno, A. Antonio Moura
Mozambique, Maputo
Universidade Eduardo Mondlane
Sliwa, Karen S.
South Africa, Cape Town
Hatter Institute for Cardiovascular Research in Africa
Smythe, Wynand A.
South Africa, Cape Town
University of Cape Town
Kramer, Nicky
South Africa, Cape Town
University of Cape Town
Badri, Motasim A.
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
South Africa, Cape Town
University of Cape Town
Francis, Veronica M.
South Africa, Cape Town
University of Cape Town
Aje, Akinyemi O.
Nigeria, Ibadan
University College Hospital, Ibadan
Barasa, Felix Ayub
Kenya, Eldoret
Moi University
Dzudie, Anastase Innocent
Cameroon, Douala
Douala General Hospital
Jones, Erika S.W.
South Africa, Cape Town
University of Cape Town
Kana, Shehu S.
Nigeria, Kano
Aminu Kano Teaching Hospital
Mntla, Phindile S.
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Mondo, Charles Kiiza
Uganda, Kampala
St. Francis Hospital Uganda
Ogah, Okechukwu Samuel
Nigeria, Ibadan
University College Hospital, Ibadan
Ogola, Elijah N.
Kenya, Nairobi
University of Nairobi
Ogunbanjo, B. G.
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Okpechi, Ikechi Gareth
South Africa, Cape Town
University of Cape Town
Shedul, Gabriel Lamkur
Nigeria, Abuja
University of Abuja
Sani, Mahmoud Umar
Nigeria, Kano
Aminu Kano Teaching Hospital
Shedul, Grace
Nigeria, Abuja
University of Abuja
Mayosi, Bongani M.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 8
Authors: 23
Affiliations: 13
Identifiers
Doi:
10.1016/j.ahj.2018.03.023
ISSN:
00028703
Research Areas
Disability
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study