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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Predictors of pregnancy complications in women with congenital heart disease
European Heart Journal, Volume 31, No. 17, Year 2010
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Description
Aims:Data regarding pregnancy outcome in women with congenital heart disease (CHD) are limited.Methods and results: In 1802 women with CHD, 1302 completed pregnancies were observed. Independent predictors of cardiac, obstetric, and neonatal complications were calculated using logistic regression. The most prevalent cardiac complications during pregnancy were arrhythmias (4.7) and heart failure (1.6). Factors independently associated with maternal cardiac complications were the presence of cyanotic heart disease (corrected/uncorrected) (P < 0.0001), the use of cardiac medication before pregnancy (P < 0.0001), and left heart obstruction (P < 0.0001). New characteristics were mechanical valve replacement (P = 0.0014), and systemic (P = 0.04) or pulmonary atrioventricular valve regurgitation related with the underlying (moderately) complex CHD (P = 0.03). A new risk score for cardiac complications is proposed. The most prevalent obstetric complications were hypertensive complications (12.2). No correlation of maternal characteristics with adverse obstetric outcome was found. The most prevalent neonatal complications were premature birth (12), small for gestational age (14), and mortality (4). Cyanotic heart disease (corrected/uncorrected) (P = 0.0003), mechanical valve replacement (P = 0.03), maternal smoking (P = 0.007), multiple gestation (P = 0.0014), and the use of cardiac medication (P = 0.0009) correlated with adverse neonatal outcome.Conclusion: In our tertiary CHD cohort, cardiac, obstetric, and neonatal complications were frequently encountered, and (new) correlations of maternal baseline data with adverse outcome are reported. A new risk score for adverse cardiac complications is proposed, although prospective validation remains necessary. © European Society of Cardiology The Author 2010. All rights reserved.
Authors & Co-Authors
Boersma, Eric E.
Netherlands, Rotterdam
Erasmus Mc
Moons, Philip
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Roos-Hesselink, Jolien W.
Netherlands, Rotterdam
Erasmus Mc
Mulder, Barbara J.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Utrecht
University Medical Center Utrecht
Vliegen, Hubert W.
Netherlands, Leiden
Leids Universitair Medisch Centrum
van Dijk, Arie P.J.
Netherlands, Nijmegen
Radboud University Medical Center
Voors, Adriaan Alexander
Netherlands, Groningen
Rijksuniversiteit Groningen
van Veldhuisen, Dirk Jan
Netherlands, Groningen
Rijksuniversiteit Groningen
Statistics
Citations: 524
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1093/eurheartj/ehq200
ISSN:
15229645
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female