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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The role of targeted selective treatments in the development of refugia-based approaches to the control of gastrointestinal nematodes of small ruminants
Veterinary Parasitology, Volume 164, No. 1, Year 2009
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Description
Anthelmintic resistance is recognised as a major problem affecting small ruminant production worldwide and now threatens the sustainability of many of these systems. One method that has been proposed to prolong the efficacy of our current anthelmintics is the maintenance of a parasite population in refugia (unexposed to a drug) which will maintain the genes for susceptibility within the parasite population. Management strategies that employ refugia-based methods include targeted or strategically timed whole flock treatments, targeted selective treatments (TST), whereby only a proportion of the flock is treated at any one time, and the dilution of resistant with susceptible parasites. The ability to effectively target anthelmintic use relies on the identification of those animals that will most benefit from treatment. This review explains the concept of refugia, describes the role of refugia-based approaches to the management of anthelmintic resistance and reviews the markers that have been studied as indicators for TSTs as well as the implementation of refugia-based strategies. Recent results suggest that targeting anthelmintic treatment on the basis of anaemia, milk production and liveweight gain may offer a means of reducing anthelmintic usage whilst still maintaining animal performance. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Kenyon, Fiona
United Kingdom, Midlothian
Moredun Research Institute
Greer, Andrew W.
United Kingdom, Midlothian
Moredun Research Institute
New Zealand, Lincoln
Lincoln University
Coles, Gerald C.
United Kingdom, Bristol
University of Bristol
Cringoli, Giuseppe
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Papadopoulos, Elias G.
Greece, Thessaloniki
Aristotle University of Thessaloniki
Cabaret, Jacques
France, Tours
Infectiologie et Santé Publique Isp
Berrag, Boumadiane
Morocco, Agdal Rabat
Institut Agronomique et Veterinaire Hassan Ii
Varady, M.
Slovakia, Kosice
Parasitological Institute of the Slovak Academy of Sciences
Van Wyk, J. A.
South Africa, Pretoria
University of Pretoria
Thomas, Eurion R.
United Kingdom, Aberystwyth
Innovis Limited
Vercruysse, Jozef
Belgium, Ghent
Universiteit Gent
Jackson, F.
United Kingdom, Midlothian
Moredun Research Institute
Statistics
Citations: 270
Authors: 12
Affiliations: 11
Identifiers
Doi:
10.1016/j.vetpar.2009.04.015
ISSN:
03044017
Study Design
Cross Sectional Study