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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection
Journal of Hepatology, Volume 45, No. 3, Year 2006
Notification
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Description
Background/Aims: Human parvovirus B19 (B19) has been identified in the serum of hepatitis B virus (HBV) infected patients. However, the effect of B19-infection on the course of HBV-associated liver disease has not previously been investigated. We examined the prevalence of B19-DNA in HBV-infected Vietnamese patients and analysed the association between co-infection and the clinical outcome of HBV-infection. Methods: Serum samples from 399 HBV-infected patients and 64 healthy individuals were analysed for the presence of B19-DNA by PCR and DNA-sequencing. Results: B19-DNA was detected in 99/463 (21.4%) individuals. The proportion of HBV-infected patients who were also co-infected with B19 was higher than the healthy controls (P < 0.001). B19-DNA was detected more frequently in patients with HBV-associated hepatocellular carcinoma compared to patients with acute and chronic HBV, HBV-associated liver cirrhosis and healthy subjects (P < 0.006). A positive correlation was also found between B19-DNA loads and both serum HBV-DNA loads and alanine aminotransferase (ρ > 0.250 and P < 0.05). Conclusions: Our findings demonstrate that B19-infection is frequent in HBV-infected Vietnamese patients. Also, a significant correlation exists between HBV/B19 co-infection and a greater likelihood of progression to more severe hepatitis B-associated liver disease. Further studies are required to determine the role of B19-infection on HBV-associated pathogenesis. © 2006 European Association for the Study of the Liver.
Authors & Co-Authors
Toan, Nguyen Linh
Germany
University Hospital of Tuebingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Song, Lehuu
Viet Nam, Hanoi
Tran Hung Dao Hospital
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Duy, Dinh Ng
Viet Nam, Hanoi
Tran Hung Dao Hospital
Binh, Vu Quoc
Viet Nam, Hanoi
354 Military Hospital
Duechting, Anja
Germany
University Hospital of Tuebingen
Kaiser, Heike
Germany
University Hospital of Tuebingen
Torresi, Joseph
Australia
Clinical Centre for Research Excellence
Kandolf, Reinhard
Germany
University Hospital of Tuebingen
Bock, C. Thomas
Germany
University Hospital of Tuebingen
Statistics
Citations: 31
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.jhep.2006.03.013
ISSN:
01688278
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study