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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Interaction of nanoparticles with proteins: Relation to bio-reactivity of the nanoparticle
Journal of Nanobiotechnology, Volume 11, No. 1, Article 26, Year 2013
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Description
Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake. © 2013 Saptarshi et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Duschl, A.
Austria, Salzburg
Universität Salzburg
Lopata, Andreas Ludwig
Australia, Townsville
James Cook University
Statistics
Citations: 849
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1186/1477-3155-11-26
ISSN:
14773155