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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Beta-synuclein gene variants and Parkinson's disease: A preliminary case-control study
Neuroscience Letters, Volume 420, No. 3, Year 2007
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Description
Aggregation and fibrillization of the alpha-synuclein protein, which is the main component of Lewy bodies, may represent important processes in the pathogenesis of Parkinson's disease (PD). Several in vivo and in vitro studies suggest that beta-synuclein may be a natural negative regulator of alpha-synuclein aggregation and fibrillization. The goal of the present study was to investigate the association of two polymorphisms (rs35035889 and rs1352303) in the beta-synuclein (SNCB) gene with PD. Our case-control study included a total of 370 case-unaffected sibling pairs and 168 case-unrelated control pairs (538 pairs total). The subjects were recruited from an ongoing study of the molecular epidemiology of PD in the Upper Midwest (USA). We employed a liberalization of the sibling transmission disequilibrium test to study the main effects of the gene variants for subjects overall and for strata defined by age at study, gender, ethnicity, clinical diagnostic certainty, dementia, and family history of PD (adjusted for age at study and gender as appropriate). The analyses were conducted for each SNCB variant separately, and also for two-locus haplotypes using score tests. Neither of the SNCB SNPs examined were associated with PD overall or in strata, and haplotype analyses were negative as well. However, one of the two SNPs (rs1352303) was associated with a delayed age at onset of PD in women. The results of this preliminary study suggest that the SNCB locus, though not a susceptibility gene for PD, might modify the age at onset of PD. © 2007 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Brighina, Laura
United States, Rochester
Mayo Medical School
Okubadejo, Njideka U.
United States, Rochester
Mayo Medical School
de Andrade, Mariza A.
United States, Rochester
Mayo Medical School
Cunningham, Julie M.
United States, Rochester
Mayo Medical School
Farrer, Matthew J.
United States, Jacksonville
Mayo Clinic in Jacksonville, Florida
Lincoln, Sarah J.
United States, Jacksonville
Mayo Clinic in Jacksonville, Florida
Rocca, Walter A.
United States, Rochester
Mayo Medical School
Maraganore, Demetrius M.
United States, Rochester
Mayo Medical School
Statistics
Citations: 20
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.neulet.2007.05.021
ISSN:
03043940
Research Areas
Genetics And Genomics
Mental Health
Study Design
Case-Control Study
Participants Gender
Female