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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of metastatic breast cancer in estrogen receptor positive patients a randomized trial comparing tamoxifen alone versus tamoxifen plus CMF
Cancer, Volume 50, No. 12, Year 1982
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Description
In a controlled clinical trial, 52 patients with ER positive metastatic breast cancer were randomly assigned to receive initial treatment with either tamoxifen alone followed by sequential cyclophosphamide, methotrexate, and 5‐fluorouracil (CMF) after tumor progression or concurrent tamoxifen plus CMF. All 52 patients entered are eligible and 50 patients were currently assessable. Response rates (CR + PR) were similar for the two treatment groups (15/24 tamoxifen alone, 17/26 tamoxifen + CMF). The median durations of survival for the two treatment groups 17.7 months and 17.1 months were also not significantly different. Significant correlations were found between level of ER and response rate and also between level of ER and response duration. From the result of this investigation it would appear that there is no advantage to the addition of chemotherapy prior to an adequate trial of hormone therapy in patients with metastatic ER positive breast cancer. Copyright © 1982 American Cancer Society
Authors & Co-Authors
Bezwoda, Werner Robert
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Derman, Dennis P.
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
de Moor, Norah G.
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Lange, Myron
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Levin, Joseph
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Statistics
Citations: 33
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1002/1097-0142(19821215)50:12<2747::AID-CNCR2820501209>3.0.CO;2-Y
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer