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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CEPH consortium map of chromosome 9
Genomics, Volume 19, No. 2, Year 1994
Notification
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Description
This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of chromosome 9. A total of 124 markers were typed in the CEPH family DNAs by 14 contributing laboratories; of these, 42 loci are ordered on the map with likelihood support of at least 1000:1. The uniquely placed markers include 31 that can be typed by PCR. A further 28 markers that can be typed by PCR are approximately positioned on the map. Multilocus linkage analysis with CR1-MAP has produced male, female, and sex-averaged maps extending for 176, 237, and 209 cM, respectively, while sex-averaged maps produced with MAPMAKER and the multiple two-point program MAP extended for 170 and 129 cM, respectively. The male map contains only two intervals greater than 10 cM, and the mean genetic distance between the 42 uniquely placed loci is 4.3 cM. However, no markers were available to anchor the map at either telomere or the centromere. The results confirm the high level of interference suggested by chiasma maps of chromosome 9. Detailed meiotic breakpoints for three of the families are shown. These can be used to provide rapid placement of any new marker without the need for statistical analysis. © 1994 Academic Press, Inc.
Authors & Co-Authors
Attwood, John
United Kingdom, London
University College London
Chiano, Mathias N.
United Kingdom, Cambridge
University of Cambridge
Collins, A.
United Kingdom, Southampton
Princess Anne Hospital
Donis-Keller, Helen
United States, St. Louis
Washington University School of Medicine in St. Louis
Dracopoli, Nicholas C.
United States, Bethesda
National Human Genome Research Institute Nhgri
Fountain, J.
United States, Cambridge
Massachusetts Institute of Technology
Falk, C.
United States, New York
New York Blood Center
Goudie, David R.
United Kingdom, Cambridge
University of Cambridge
Gusella, James F.
United States, Boston
Massachusetts General Hospital
Haines, Jonathan L.
United States, Boston
Massachusetts General Hospital
Armour, John A.L.
United Kingdom, Leicester
University of Leicester
Jeffreys, Alec J.
United Kingdom, Leicester
University of Leicester
Kwiatkowski, D.
United States, Boston
Brigham and Women's Hospital
Lathrop, Mark G.
France, Paris
Fondation Jean Dausset - Ceph
Matise, Tara Cox
United States, Pittsburgh
University of Pittsburgh
Northrup, H.
United States, Houston
University of Texas Medical School at Houston
Kunkle, Brian W.
United States, Durham
Duke University Medical Center
Phillips, John Atlas
United States, Nashville
Vanderbilt University Medical Center
Retief, Andries E.
South Africa, Stellenbosch
Stellenbosch University
Robson, Elizabeth B.
United Kingdom, London
University College London
Shields, Denis Colm
United Kingdom, Southampton
Princess Anne Hospital
Slaugenhaupt, S.
United States, Boston
Massachusetts General Hospital
Vergnaud, Gilles
France, Vert-le-petit
Centre D'études du Bouchet
Weber, James L.
United States, Marshfield
Marshfield Clinic
Weissenbach, Jean S.
France, Paris
Institut Pasteur, Paris
White, Raymond L.
United States, Salt Lake City
The University of Utah
Yates, John R.W.
United Kingdom, Cambridge
University of Cambridge
Povey, Susanne M.
United Kingdom, London
University College London
Statistics
Citations: 28
Authors: 28
Affiliations: 20
Identifiers
Doi:
10.1006/geno.1994.1049
ISSN:
08887543
e-ISSN:
10898646
Research Areas
Genetics And Genomics
Study Approach
Quantitative
Participants Gender
Male
Female