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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The level and duration of RSV-specific maternal IgG in infants in kilifi Kenya
PLoS ONE, Volume 4, No. 12, Article e8088, Year 2009
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Description
Background: Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between these levels and protection from infection are poorly defined. Methods: A birth cohort (n=635) in rural Kenya, was studied intensively to monitor infections and describe age-related serological characteristics. RSV specific IgG antibody (Ab) in serum was measured by the enzyme linked immunosorbent assay (ELISA) in cord blood, consecutive samples taken 3 monthly, and in paired acute and convalescent samples. A linear regression model was used to calculate the rate of RSV-matAb decline. The effect of risk factors on cord blood titres was investigated. Results: The half-life of matAb in the Kenyan cohort was calculated to be 79 days (95% confidence limits (CL): 76-81 days). Ninety seven percent of infants were born with RSV-matAb. Infants who subsequently experienced an infection in early life had significantly lower cord titres of anti-RSV Ab in comparison to infants who did not have any incident infection in the first 6 months (P=0.011). RSV infections were shown to have no effect on the rate of decay of RSV-matAb. Conclusion: Maternal-specific RSV Ab decline rapidly following birth. However, we provide evidence of protection against severe disease by RSV-matAb during the first 6-7 months. This suggests that boosting maternal-specific Ab by RSV vaccination may be a useful strategy to consider. © 2009 Ochola et al.
Authors & Co-Authors
Ochola, Rachel
Unknown Affiliation
Sande, Charles Jumba
Unknown Affiliation
Fegan, Greg
Unknown Affiliation
Scott, Paul D.
Unknown Affiliation
Medley, Graham F.
Unknown Affiliation
Cane, Patricia A.
Unknown Affiliation
Nokes, David James
Unknown Affiliation
Statistics
Citations: 149
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0008088
e-ISSN:
19326203
Research Areas
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya