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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The influence of bacille Calmette-Guérin vaccine strain on the immune response against tuberculosis: A randomized trial
American Journal of Respiratory and Critical Care Medicine, Volume 185, No. 2, Year 2012
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Description
Approximately 100 million doses of bacille Calmette-Guérin (BCG) vaccine are given each year to protect against tuberculosis (TB). More than 20 genetically distinct BCG vaccine strains are in use worldwide. Previous studies suggest that BCG vaccine strain influences the immune response and protection against TB. Current data on which BCG vaccine strain induces the optimal immune response in humans are insufficient. Objectives: To compare the immuneresponse to three different BCG vaccine strains given to infants at birth. Methods: Newborn infants in a tertiary women's hospital were immunized at birth with one of three BCG vaccine strains. A stratified randomization according to the mother's region of birth was used. Measurements and Main Results: The presence of mycobacterial-specific polyfunctional CD4 T cells measured by flow cytometry 10 weeks after immunization. Of the 209 infants immunized, data from 164 infants were included in the final analysis(BCG-Denmark,n=54; BCG-Japan, n=54; BCG-Russia, n=57). The proportion of polyfunctional CD4 T cells was significantly higher in infants immunized with BCG-Denmark (0.013%) or BCG-Japan (0.016%) than with BCG-Russia (0.007%) (P = 0.018 and P = 0.003, respectively). Infants immunized with BCG-Japan had higher concentrations of secreted Th1 cytokines; infants immunized with BCG-Denmark had higher proportions of CD107-expressing cytotoxic CD4 T cells. Conclusions: There are significant differences in the immune response induced by different BCG vaccine strains in newborn infants. Immunization with BCG-Denmark or BCG-Japan induced higher frequencies of mycobacterial-specific polyfunctional and cytotoxic T cells and higher concentrations of Th1 cytokines. These findings have potentially important implications for global antituberculosis immunization policies and future tuberculosis vaccine trials. Copyright © 2012 by the American Thoracic Society.
Authors & Co-Authors
Ritz, Nicole
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Dutta, Binita
Australia, Melbourne
Murdoch Children's Research Institute
Donath, Susan M.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Casalaz, Dan M.
Australia, Melbourne
Mercy Hospital for Women
Connell, Tom G.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Tebruegge, Marc O.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Robins-Browne, Roy Michael
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Britton, Warwick J.
Australia, Sydney
The University of Sydney
Curtis, Nigel C.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Statistics
Citations: 114
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1164/rccm.201104-0714OC
ISSN:
1073449X
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Participants Gender
Female