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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Maternal mortality associated with tuberculosis-HIV-1 co-infection in Durban, South Africa
AIDS, Volume 15, No. 14, Year 2001
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Description
Objectives: To document the impact of tuberculosis and HIV-1 on maternal mortality. Design: Prospective study, 1997 and 1998; retrospective analysis, 1996. Participants: Known maternal deaths, defined as the death of a mother within a year post-delivery, were studied in Durban, KwaZulu Natal. The HIV-1 status, presence of tuberculosis, maternal clinical features and perinatal outcomes were documented. The overall as well as HIV-1 and tuberculosis-specific maternal mortality rates for the hospital were calculated. The attributable fraction of deaths as a result of HIV-1 was calculated in the overall group and in those with tuberculosis co-infection. Results: A total of 50 518 deliveries and 101 maternal deaths were recorded. Of the deaths, 29.7% (30/101) were HIV-1 infected. The overall mortality rate was 200/100 000; for HIV-1-infected women this was 323.3/100 000, HIV-1-negative mothers, 148.6/100 000 live births. The attributable fraction of overall deaths as a result of HIV-1 was 15.9% Fourteen of the 15 mothers with tuberculosis were HIV-1 co-infected. The mortality rate for tuberculosis and HIV-1 co-infection was 121.7/1000; for tuberculosis without HIV-1 co-infection, 38.5/1000. Fifty-four per cent of maternal deaths caused by tuberculosis were attributable to HIV-1 infection. Thirty-five per cent of maternal deaths were associated with stillbirths; perinatal outcomes were no different between groups of mothers with tuberculosis, HIV-1 or neither infection. Conclusion: Tuberculosis and HIV-1 are emerging as significant contributors to maternal mortality in KwaZulu Natal. Any attempt to improve maternal health must also include careful screening and investigation for tuberculosis in high-risk pregnant women. © 2001 Lippincott Williams & Wilkins.
Authors & Co-Authors
Khan, Munira
South Africa, Tygerberg
South African Medical Research Council
Pillay, Thillagavathie
South Africa, Durban
University of Kwazulu-natal
United Kingdom, Oxford
Nuffield Department of Medicine
Moodley, Jagdisea M.
South Africa, Durban
University of Kwazulu-natal
Connolly, Catherine Anne
Unknown Affiliation
Statistics
Citations: 177
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1097/00002030-200109280-00016
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
South Africa
Participants Gender
Female