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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk
Carcinogenesis, Volume 31, No. 10, Year 2010
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Description
Although inflammation is emerging as a candidate prostate cancer risk factor, the T-helper cytokine-rich [interleukins (IL)-5, 13 and 4] chromosomal region at 5q31.1 has been implicated in prostate cancer pathogenesis. In particular, IL-4 has been associated with prostate cancer progression, whereas the IL-4 -589C>T (rs2243250) promoter variant has been associated with differential gene expression. We genotyped rs2243250 and 11 tag single-nucleotide polymorphisms (SNPs) spanning 200 kb across the 5q31.1 region on 825 cases and 732 controls from the Risk Factors for Prostate Cancer Study. The minor alleles of rs2243250 and an IL-4 tagSNP rs2227284 were associated with a small increase in prostate cancer risk. Per allele odds ratios (ORs) are 1.32 [95% confidence interval (CI) 1.08-1.61, P = 0.006] and 1.26 (95% CI 1.07-1.48, P = 0.005), respectively. Although these associations were not replicated in an analysis of the Melbourne Collaborative Cohort Study, including 810 cases and 1733 controls, no clinicopathological characteristic was implicated for this divergence. Correlating rs2243250 genotypes to IL-4 gene transcript levels and circulating IL-4 plasma levels, we observe in contrast to previous reports, a non-significant trend toward the minor T-allele decreasing the likelihood of IL-4 activity. From our observed association between a low IL-4 producing promoter T-allele and prostate cancer risk, our study suggests an antitumor role for IL-4 in prostate cancer. Although we saw no association for IL-5 or IL-13 gene variants and prostate cancer risk, our findings call for further evaluation of IL-4 as a contributor to prostate cancer susceptibility. © The Author 2010. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Tindall, Elizabeth A.
Australia, Sydney
Unsw Sydney
Severi, Gianluca
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Hoang, Hoa N.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Ma, Cindy S.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
Unsw Sydney
Fernández, Pedro Luís
South Africa, Tygerberg
Tygerberg Hospital
Southey, Melissa Caroline
Australia, Melbourne
University of Melbourne
English, D. R.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Hopper, John Llewelyn
Australia, Melbourne
University of Melbourne
Heyns, Christopher F.
South Africa, Tygerberg
Tygerberg Hospital
Tangye, Stuart G.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
Unsw Sydney
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Hayes, Vanessa M.
Australia, Sydney
Unsw Sydney
Statistics
Citations: 40
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1093/carcin/bgq081
ISSN:
01433334
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study
Study Approach
Quantitative