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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel
Biomaterials, Volume 33, No. 7, Year 2012
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Description
A targeted intracellular delivery system of paclitaxel (PTX) was successfully developed based on redox-sensitive hyaluronic acid-deoxycholic acid (HA-ss-DOCA) conjugates. The conjugates self-assembled into nano-size micelles in aqueous media and exhibited excellent drug-loading capacities (34.1%) and entrapment efficiency (93.2%) for PTX. HA-ss-DOCA micelles were sufficiently stable at simulated normal physiologic condition but fast disassembled in the presence of 20m. m reducing agent, glutathione. Invitro drug release studies showed that the PTX-loaded HA-ss-DOCA micelles accomplished rapid drug release under reducing condition. Intracellular release of fluorescent probe nile red indicated that HA-ss-DOCA micelles provide an effective approach for rapid transport of cargo into the cytoplasm. Enhanced cytotoxicity of PTX-loaded HA-ss-DOCA micelles further confirmed that the sensitive micelles are more potent for intracellular drug delivery as compared to the insensitive control. Based on flow cytometry and confocal microscopic analyses, observations revealed that HA-ss-DOCA micelles were taken up to human breast adenocarcinoma cells (MDA-MB-231) via HA-receptor mediated endocytosis. Invivo investigation of micelles in tumor-bearing mice confirmed that HA-ss-DOCA micelles possessed much higher tumor targeting capacity than the insensitive control. These results suggest that redox-sensitive HA-ss-DOCA micelles hold great potential as targeted intracellular delivery carriers of lipophilic anticancer drugs. © 2011.
Authors & Co-Authors
Li, Jing
China, Nanjing
China Pharmaceutical University
Huo, Meirong
China, Nanjing
China Pharmaceutical University
Wang, Jing
China, Nanjing
China Pharmaceutical University
Zhou, Jianping
China, Nanjing
China Pharmaceutical University
Mohammad, Jumah M.
China, Nanjing
China Pharmaceutical University
Iraq, Baghdad
Mustansiriyah University
Zhang, Yinlong
China, Nanjing
China Pharmaceutical University
Zhu, Qinnv
China, Nanjing
China Pharmaceutical University
Waddad, Ayman Y.
China, Nanjing
China Pharmaceutical University
Zhang, Qiang
China, Beijing
Peking University
Statistics
Citations: 414
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.biomaterials.2011.11.022
ISSN:
01429612
e-ISSN:
18785905
Research Areas
Cancer