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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever
Arthritis and Rheumatism, Volume 56, No. 5, Year 2007
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Description
Objective. Familial Mediterranean fever (FMF), the prototype of autoinflammatory disorders, is caused by recessive mutations in the MEFV gene. Some FMF patients develop renal amyloidosis, a potentially fatal condition. This complication has mainly been associated with the M694V mutation, although the different study designs, small numbers of patients, and/or evaluation of few or no covariables calls this association into question. The aim of this study was to examine the controversial issue of amyloidosis susceptibility in FMF by determining the relative contributions of MEFV and numerous epidemiologic factors to the risk of renal amyloidosis. Methods. Online questionnaires were completed at the MetaFMF database by patients at 35 centers in 14 countries. Using a standardized mode of data collection, we retrieved crude initial data from over half of the genetically confirmed FMF patients referred worldwide until May 2003 (2,482 cases, including 260 patients who developed renal amyloidosis). Results. Amyloid nephropathy was present in 11.4% of the cases. In the total study population, country of recruitment was the leading risk factor for this manifestation (odds ratio 3.2 [95% confidence interval 1.8-5.9]), followed by M694V homozygosity, proband status, and disease duration. Differing results were found when countries were stratified. Conclusion. Country of recruitment, rather than MEFV genotype, is the key risk factor for renal amyloidosis in FMF. This risk, which parallels infant mortality rates, indicates a possible environmental origin of amyloidosis susceptibility. The patient's country should be considered in addition to MEFV genotype as an indication for prophylactic colchicine, a treatment suggested for asymptomatic individuals who are incidentally discovered to be M694V homozygous. © 2007, American College of Rheumatology.
Authors & Co-Authors
Touïtou, Isabelle
France, Montpellier
Hopital Arnaud de Villeneuve
Sarkisian, Tamara
Armenia, Yerevan
National Academy of Sciences of the Republic of Armenia
Medlej-Hashim, Myrna
Lebanon, Beirut
Université Saint-joseph de Beyrouth
Tunca, Mehmet
Turkey, Izmir
Dokuz Eylül Üniversitesi
Livneh, Avi
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Cattan, Daniel
France, Villeneuve-saint-georges
Centre Hospitalier Intercommunal de Villeneuve-saint-georges
Yalçinkaya, Fatos
Turkey, Ankara
Ankara Üniversitesi
Ozen, Seza
Turkey, Ankara
Hacettepe Üniversitesi
Majeed, Hassan Abdel
Jordan, Irbid
Jordan University of Science and Technology
Özdoǧan, Huri
Turkey, Istanbul
Istanbul Üniversitesi
Kastner, Daniel L.
United States, Bethesda
National Institute of Arthritis and Musculoskeletal and Skin Diseases Niams
Booth, David R.
Australia, Parramatta
The Westmead Institute for Medical Research
Ben-Chetrit, Eldad
Israel, Jerusalem
Hadassah University Medical Centre
Pugnère, Denis
France, Montpellier
Hopital Arnaud de Villeneuve
Michelon, Cécile
France, Montpellier
Hopital Arnaud de Villeneuve
Seguret, Fabienne
France, Montpellier
Hopital Arnaud de Villeneuve
Gershoni-Baruch, Ruth
Israel, Haifa
Rambam Health Care Campus Israel
Statistics
Citations: 247
Authors: 17
Affiliations: 14
Identifiers
Doi:
10.1002/art.22507
ISSN:
00043591
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Grounded Theory