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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine
Journal of Immunology, Volume 188, No. 10, Year 2012
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Description
RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergoing clinical trials. We report an analysis of cellular immune response to component Ags of RTS,S - hepatitis B surface Ag (HBs) and P. falciparum circumsporozoite (CS) protein - among Tanzanian children in a phase IIb RTS,S/AS01 E trial. RTS,S/AS01 E vaccinees make stronger T cell IFN-γ, CD69, and CD25 responses to HBs peptides than do controls, indicating that RTS,S boosts pre-existing HBs responses. T cell CD69 and CD25 responses to CS and CS-specific secreted IL-2 were augmented by RTS,S vaccination. Importantly, more than 50% of peptide-induced IFN- γ + lymphocytes were NK cells, and the magnitude of the NK cell CD69 response to HBs peptides correlated with secreted IL-2 concentration. CD69 and CD25 expression and IL-2 secretion may represent sensitive markers of RTS,S-induced, CS-specific T cells. The potential for T cell-derived IL-2 to augment NK cell activation in RTS,S-vaccinated individuals, and the relevance of this for protection, needs to be explored further. Copyright © 2012 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Horowitz, Amir
Unknown Affiliation
Hafalla, Julius Clemence R.
Unknown Affiliation
King, Elizabeth C.
Unknown Affiliation
Lusingu, John Peter Andrea
Unknown Affiliation
Dekker, Denise Myriam
Unknown Affiliation
Leach, Amanda
Unknown Affiliation
Moris, Philippe J.
Unknown Affiliation
Cohen, Joe D.
Unknown Affiliation
Vekemans, Johan
Unknown Affiliation
Villafana, Tonya L.
Unknown Affiliation
Corran, Patrick H.
Unknown Affiliation
Bejon, Philip A.
Unknown Affiliation
Drakeley, Chris J.
Unknown Affiliation
Von-Seidlein, Lorenz
Unknown Affiliation
Riley, Eleanor M.
Unknown Affiliation
Statistics
Citations: 78
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.4049/jimmunol.1102710
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Infectious Diseases
Maternal And Child Health