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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Monocyte chemotactic protein-1 secretion and expression after Toxoplasma gondii infection in vitro depend on the stage of the parasite
FEMS Microbiology Letters, Volume 214, No. 1, Year 2002
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Description
Infection of human fibroblasts with tachyzoites of RH and Prugniaud strains, two different strains of Toxoplasma gondii, significantly increased monocyte chemotactic protein (MCP)-1 secretion contrary to what happened with bradyzoites of the cystogenetic strain. Quantification of MCP-1 mRNA by RT-PCR showed that this phenomenon is regulated at the transcriptional level. Thus, the stage of parasite can be deciding in MCP-1 induction since only tachyzoites induced MCP-1 expression and secretion. MCP-1 induced by tachyzoites could be involved in cell recruitment, as shown by the quantification of MCP1 ARNm by real-time PCR (LightCycler, Roche Diagnostics), in the pathogenesis of T. gondii infection. © 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Brenier-Pinchart, Marie Pierre
France, Saint Martin D'heres
Université Grenoble Alpes
Vigan-Womas, Inès
France, Saint Martin D'heres
Université Grenoble Alpes
Marche, Patrice N.
France, Saint Martin D'heres
Université Grenoble Alpes
Gross, Uwe
Germany, Gottingen
Georg-august-universität Göttingen
Ambroise-Thomas, Pierre
France, Saint Martin D'heres
Université Grenoble Alpes
Pelloux, Hervé
France, Saint Martin D'heres
Université Grenoble Alpes
Statistics
Citations: 18
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/S0378-1097(02)00842-X
ISSN:
03781097