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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
African Burkitt lymphoma: Age-specific risk and correlations with malaria biomarkers
American Journal of Tropical Medicine and Hygiene, Volume 84, No. 3, Year 2011
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Description
African Burkitt lymphoma is an aggressive B-cell, non-Hodgkin lymphoma linked to Plasmodium falciparum malaria. Malaria biomarkers related to onset of African Burkitt lymphoma are unknown. We correlated agespecific patterns of 2,602 cases of African Burkitt lymphoma (60% male, mean ± SD age = 7.1 ± 2.9 years) from Uganda, Ghana, and Tanzania with malaria biomarkers published from these countries. Age-specific patterns of this disease and mean multiplicity of P. falciparum malaria parasites, defined as the average number of distinct genotypes per positive blood sample based on the merozoite surface protein-2 assessed by polymerase chain reaction, were correlated and both peaked between 5 and 9 years. This pattern, which was strong and consistent across regions, contrasted parasite prevalence, which peaked at 2 years and decreased slightly, and geometric mean parasite density, which peaked between 2 and 3 years and decreased sharply. Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Emmanuel, Benjamin
United States, Rockville
National Cancer Institute Nci
Kawira, Esther Lehman
Unknown Affiliation
Ogwang, Martin David
Uganda, Gulu
St. Mary's Hospital Lacor - Uganda
Wabinga, Henry R.
Uganda, Kampala
Makerere University
Magatti, Josiah
United States
Interchurch Medical Assistance
Nkrumah, Francis K.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Neequaye, Janet E.
Ghana, Accra
Korle bu University Teaching Hospital
Bhatia, Kishor G.
United States, Rockville
National Cancer Institute Nci
Brubaker, Glen R.
United States
Interchurch Medical Assistance
Biggar, Robert John
Denmark, Copenhagen
Statens Serum Institut
Mbulaiteye, Sam M.
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 36
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2011.10-0450
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Ghana
Tanzania
Uganda
Participants Gender
Male