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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Adverse systemic reactions to treatment of onchocerciasis with ivermectin at normal and high doses given annually or three-monthly
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 98, No. 8, Year 2004
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Description
In Cameroon, a 3-year randomized, double-blind controlled trial was conducted to determine if ivermectin, given at 3-monthly intervals and/or at high doses (800 μg/kg), had a greater effect on adult Onchocerca volvulus than standard annual doses of 150 >μg/kg. Adverse reactions were recorded and analysed in a logistic regression model with random effects to assess the influence of the dose and rhythm of treatment on their occurrence. After the first dose, 3-monthly treatment was associated with a clearly reduced risk of reactions, especially oedematous swellings, pruritus and back-pain. Oedematous swellings and subjective ocular troubles were found to be associated with high doses of ivermectin. These results reinforce former parasitological conclusions that it would be desirable to evaluate the feasibility and effects on transmission of large-scale 3-monthly treatments with standard doses of ivermectin for onchocerciasis control. Owing to the unexpected ocular reactions, the use of high doses to counteract any future resistance of O. volvulus to ivermectin should be considered with caution. © 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Kamgno, Joseph
Cameroon, Yaounde
Centre Pasteur du Cameroun
Gardon, Jacques
Cameroon, Yaounde
Centre Pasteur du Cameroun
Gardon-Wendel, Nathalie
Cameroon, Yaounde
Centre Pasteur du Cameroun
Demanga-Ngangue, A.
Cameroon, Douala
Délégation Provinciale de la Santé Publique du Littoral
Duke, Brian O.L.P.J.
United Kingdom, Lancaster
River Blindness Foundation
Boussinesq, Michel
Cameroon, Yaounde
Centre Pasteur du Cameroun
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 49
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.trstmh.2003.10.018
ISSN:
00359203
Research Areas
Disability
Health System And Policy
Infectious Diseases
Study Locations
Cameroon