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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
Journal of Virology, Volume 81, No. 5, Year 2007
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Description
The importance of HLA class I-restricted CD8 T-cell responses in the control of human immunodeficiency virus (HIV) infection is generally accepted. While several studies have shown an association of certain HLA class I alleles with slower disease progression, it is not fully established whether this effect is mediated by HIV-specific CD8 T-cell responses restricted by these alleles. In order to study the influence of the HLA class I alleles on the HIV-specific CD8 T-cell response and on viral control, we have assessed HIV-specific epitope recognition, plasma viral load, and expression of HLA class I alleles in a cohort of HIV-seropositive bar workers. Possession of the HLA class I alleles B5801, B8101, and B0702 was associated with a low median viral load and simultaneously with a broader median recognition of Gag epitopes compared to all other HLA alleles (twofold increase) (P = 0.0035). We further found an inverse linear relationship between the number of Gag epitopes recognized and the plasma viral load (R = -0.36; P = 0.0016). Particularly, recognition of multiple epitopes within two regions of Gag (amino acids [aa] 1 to 75 and aa 248 to 500) was associated with the maintenance of a low steady-state viremia, even years after acute infection. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Geldmacher, Christof
Tanzania, Mbeya
Referral Hospital
Germany, Munich
Ludwig-maximilians-universität München
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Currier, Jeffrey R.
United States, Rockville
U.s. Military Hiv Research Program
Herrmann, Eva
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Haule, Antelmo
Tanzania, Mbeya
Referral Hospital
Kuta, Ellen G.
United States, Rockville
U.s. Military Hiv Research Program
McCutchan, Francine E.
United States, Rockville
U.s. Military Hiv Research Program
Njovu, Lilian
Tanzania, Mbeya
Referral Hospital
Geis, Steffen
Tanzania, Mbeya
Referral Hospital
Hoffmann, Oliver
Tanzania, Mbeya
Referral Hospital
Maboko, Leonard L.
Tanzania, Mbeya
Referral Hospital
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Birx, Deborah L.
United States, Rockville
U.s. Military Hiv Research Program
Meyerhans, Andreas
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Cox, Josephine H.
United States, Rockville
U.s. Military Hiv Research Program
Höelscher, Michael
Germany, Munich
Ludwig-maximilians-universität München
Statistics
Citations: 172
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.01847-06
ISSN:
0022538X
Research Areas
Infectious Diseases
Study Design
Cohort Study