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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Ameliorating effect of chicory (Chichorium intybus L.) fruit extract against 4-tert-octylphenol induced liver injury and oxidative stress in male rats
Food and Chemical Toxicology, Volume 72, Year 2014
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Description
The current study was carried out to elucidate the modulating effect of chicory (Cichorium intybus L.) fruit extract (CFR) against 4-tert-OP induced oxidative stress and hepatotoxicity in male rats. Rats were divided into four groups and treated for 8. weeks as follow: group 1: normal control-treated (saline); group 2: chicory fruit extract-treated (100. mg/kg); group 3: 4-tert-OP treated; group 4: 4-tert-OP plus chicory fruit extract. The obtained results revealed that rats which received 4-tert-OP showed a significant increase in liver TBARS and bilirubin, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) activities. While a significant decrease in the levels of GSH, SOD, catalase recorded. On the other hand, CFR extract succeeded to modulate these observed abnormalities resulting from 4-tert-OP as indicated by the reduction of TBARS and the pronounced improvement of the investigated biochemical and antioxidant parameters. Histopathological evidence, together with observed PCNA and DNA fragmentation, supported the detrimental effect of 4-tert-OP and the ameliorating effect of CFR extract on liver toxicity. So, it could be concluded that chicory has a promising role and it worth to be considered as a natural substance for ameliorating the oxidative stress and hepatic injury induced by 4-tert-OP compound. © 2014 Elsevier Ltd.
Authors & Co-Authors
Saggu, Shalini
Saudi Arabia, Tabuk
University of Tabuk
Sakeran, Mohamed I.
Egypt, Tanta
Tanta University
Saudi Arabia, Tabuk
University of Tabuk
Zidan, Nahla Salah
Egypt, Kafr El-sheikh
Faculty of Specific Education
Tousson, Ehab Moustafa
Egypt, Tanta
Tanta University
Mohan, Anand Raj
India, Phagwara
Lovely Professional University
Rehman, Hasibur
Saudi Arabia, Tabuk
University of Tabuk
Statistics
Citations: 171
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.fct.2014.06.029
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Genetics And Genomics
Violence And Injury
Participants Gender
Male