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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Surveillance of human rotaviruses in 2007-2011, Hungary: Exploring the genetic relatedness between vaccine and field strains
Journal of Clinical Virology, Volume 55, No. 2, Year 2012
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Description
Background: The availability of rotavirus vaccines has resulted in an intensification of post vaccine strain surveillance efforts worldwide to gain information on the impact of vaccines on prevalence of circulating rotavirus strains. Objectives: In this study, the distribution of human rotavirus G and P types in Hungary is reported. In addition, the VP4 and VP7 genes of G1P[8] strains were sequenced to monitor if vaccine-derived strains were introduced and/or some strains/lineages were selected against. Study design: The study was conducted in 8 geographic areas of Hungary between 2007 and 2011. Rotavirus positive stool samples were collected from diarrheic patients mostly <5. years of age. Viral RNA was amplified by multiplex genotyping RT-PCR assay, targeting the medically most important G and P types. When needed, sequencing of the VP7 and VP4 genes was performed. Results: In total, 2380 strains were genotyped. During the 5-year surveillance we observed the dominating prevalence of genotype G1P[8] (44.87%) strains, followed by G4P[8] (23.4%), G2P[4] (14.75%) and G9P[8] (6.81%) genotypes. Uncommon strains were identified in a low percentage of samples (4.12%). Phylogenetic analysis of 318 G1P[8] strains identified 55 strains similar to the Rotarix strain (nt sequence identities; VP7, up to 97.9%; VP4, up to 98.5%) although their vaccine origin was unlikely. Conclusions: Current vaccines would have protected against the majority of identified rotavirus genotypes. A better understanding of the potential long-term effect of vaccine use on epidemiology and evolutionary dynamics of co-circulating wild type strains requires continuous strain surveillance. © 2012 Elsevier B.V.
Authors & Co-Authors
László, Brigitta
Hungary, Debrecen
Általános Orvostudományi Kar
Hungary, Budapest
Magyar Tudomanyos Akademia
Kónya, József
Hungary, Debrecen
Általános Orvostudományi Kar
Dandár, Eszter
Hungary, Budapest
Magyar Tudomanyos Akademia
Deák, Judit
Hungary, Szeged
Szegedi Tudományegyetem Szte
Farkas, Ágnes
Hungary, Budapest
National Center for Epidemiology
Gray, Jim J.
United Kingdom, Norwich
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Grósz, Gábor
Hungary, Budapest
Dr. György Radó Military Medical Centre
Iturriza-Gómara, Miren
United Kingdom, London
Public Health England
Jakab, Ferenc
Hungary, Pecs
Pécsi Tudományegyetem
Juhász, Ágnes
Hungary, Debrecen
Hungarian National Public Health and Medical Officer Service
Kisfali, Péter
Hungary, Pecs
Pécsi Tudományegyetem
Kovács, Julianna
Hungary
Pediatrics Health Center
Lengyel, György
Hungary, Budapest
Dr. György Radó Military Medical Centre
Martella, Vito
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Melegh, Béla I.
Hungary, Pecs
Pécsi Tudományegyetem
Mészáros, Júlia
Hungary, Debrecen
Hungarian National Public Health and Medical Officer Service
Molnár, Péter A.
Hungary, Budapest
Szent Laszlo Hospital
Nyúl, Zoltán
Hungary, Pecs
Kerpel-fronius Ödön Center of Child Health
Papp, Hajnalka
Hungary, Budapest
Magyar Tudomanyos Akademia
Pátri, László
Hungary, Pecs
Pátri-med bt
Puskás, Erzsébet
Hungary, Miskolc
Hungarian National Public Health and Medical Officer Service
Sántha, Ildikó
Hungary, Miskolc
Hungarian National Public Health and Medical Officer Service
Schneider, Ferenc
Hungary, Szombathely
Markusovszky Teaching Hospital
Szomor, Katalin N.
Hungary, Budapest
National Center for Epidemiology
Tóth, András József
Hungary, Budapest
Szent Laszlo Hospital
Tóth, Erzsébet
Hungary, Nyiregyhaza
Hungarian National Public Health and Medical Officer Service
Szuács, György
Kuwait, Kuwait City
Kuwait University
Bányai, Krisztián
Hungary, Budapest
Magyar Tudomanyos Akademia
Statistics
Citations: 28
Authors: 28
Affiliations: 18
Identifiers
Doi:
10.1016/j.jcv.2012.06.016
ISSN:
13866532
e-ISSN:
18735967
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study