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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Plasma stearoyl-CoA desaturase indices: Association with lifestyle, diet, and body composition
Obesity, Volume 21, No. 3, Year 2013
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Description
Objective: Stearoyl-coenzyme A desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism. Increased hepatic SCD1 activity is associated with obesity and obesity-related diseases. We examined the relations of two plasma SCD activity indices (16:1n-7/16:0, 18:1n-9/18:0) with body composition, and the association of lifestyle and dietary variables with the plasma SCD indices. Design and Methods: This population-based, cross-sectional study of 2021 elderly (71-74 y) men and women from the Hordaland Health Study in Western Norway was conducted using a validated food frequency questionnaire, body composition measurements by dual-energy X-ray absorptiometry and determination of the plasma fatty acid profile. Results: In multivariate regression analyses, plasma SCD indices were positively associated with BMI and body fat (P < 0.001 for both). From the 2.5th to 97.5th percentiles of plasma SCD-16 and SCD-18 indices, fat mass differed by about 8 kg and 5 kg, respectively. Intake of polyunsaturated fatty acids were negatively associated with SCD-16 (partial r = -0.30) and SCD-18 (partial r = -0.24) (P < 0.001 for both). Alcohol intake was positively associated with SCD-16 (partial r = 0.26) and SCD-18 (partial r = 0.16) (P < 0.001 for both), whereas coffee consumption and physical activity were inversely associated with SCD-16 (P = 0.026 and P = 0.006, respectively) and SCD-18 (P = 0.001 and P = 0.022, respectively). Conclusions: In this elderly population, plasma markers of SCD1 activity are associated with increased adiposity. Furthermore, modifiable dietary habits and lifestyle are associated with plasma SCD indices. These results suggest that SCD1 activity may be a promising target for weight control. Copyright © 2012 The Obesity Society.
Authors & Co-Authors
Vinknes, Kathrine J.
Norway, Oslo
Medisinske Fakultet
Elshorbagy, Amany K.
United Kingdom, Oxford
University of Oxford
Egypt, Alexandria
Faculty of Medicine
Nurk, Eha
Norway, Oslo
Medisinske Fakultet
Estonia, Tallinn
Tervise Arengu Instituut
Drevon, Christian André
Norway, Oslo
Medisinske Fakultet
Gjesdal, Clara Gram
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Tell, Grethe Seppola
Norway, Bergen
Universitetet I Bergen
Nygård, Ottar Kjell
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Vollset, Stein Emil
Norway, Bergen
Universitetet I Bergen
Norway, Oslo
Folkehelseinstituttet
Refsum, Helga M.
Norway, Oslo
Medisinske Fakultet
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 56
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1002/oby.20011
ISSN:
19307381
e-ISSN:
1930739X
Research Areas
Food Security
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male
Female