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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cytoplasmic incompatibility as a means of controlling culex pipiens quinquefasciatus mosquito in the islands of the South-Western Indian Ocean
PLoS Neglected Tropical Diseases, Volume 5, No. 12, Article e1440, Year 2011
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Description
The use of the bacterium Wolbachia is an attractive alternative method to control vector populations. In mosquitoes, as in members of the Culex pipiens complex, Wolbachia induces a form of embryonic lethality called cytoplasmic incompatibility, a sperm-egg incompatibility occurring when infected males mate either with uninfected females or with females infected with incompatible Wolbachia strain(s). Here we explore the feasibility of the Incompatible Insect Technique (IIT), a species-specific control approach in which field females are sterilized by inundative releases of incompatible males. We show that the Wolbachia wPip(Is) strain, naturally infecting Cx. p. pipiens mosquitoes from Turkey, is a good candidate to control Cx. p. quinquefasciatus populations on four islands of the south-western Indian Ocean (La Réunion, Mauritius, Grande Glorieuse and Mayotte). The wPip(Is) strain was introduced into the nuclear background of Cx. p. quinquefasciatus mosquitoes from La Réunion, leading to the LR[wPip(Is)] line. Total embryonic lethality was observed in crosses between LR[wPip(Is)] males and all tested field females from the four islands. Interestingly, most crosses involving LR[wPip(Is)] females and field males were also incompatible, which is expected to reduce the impact of any accidental release of LR[wPip(Is)] females. Cage experiments demonstrate that LR[wPip(Is)] males are equally competitive with La Réunion males resulting in demographic crash when LR[wPip(Is)] males were introduced into La Réunion laboratory cages. These results, together with the geographic isolation of the four south-western Indian Ocean islands and their limited land area, support the feasibility of an IIT program using LR[wPip(Is)] males and stimulate the implementation of field tests for a Cx. p. quinquefasciatus control strategy on these islands. © 2011 Atyame et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3243720/bin/pntd.0001440.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3243720/bin/pntd.0001440.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3243720/bin/pntd.0001440.s003.doc
Authors & Co-Authors
Atyame, Célestine M.
France, Montpellier
Institut Des Sciences de L’evolution de Montpellier
Pasteur, Nicole
France, Montpellier
Institut Des Sciences de L’evolution de Montpellier
Dumas, Emilie
France, Montpellier
Institut Des Sciences de L’evolution de Montpellier
Tortosa, Pablo
France, Ste Clotilde
Centre de Recherche et de Veille Sur Les Maladies Emergentes Dans L'océan Indien
France, Saint-denis
Université de la Réunion
Tantely, Michaël Luciano
Madagascar, Antananarivo
Université D'antananarivo
Pocquet, Nicolas
France
Agence Régionale de Santé Ars Océan Indien
Licciardi, Séverine
France, Ste Clotilde
Centre de Recherche et de Veille Sur Les Maladies Emergentes Dans L'océan Indien
France, Paris
Cirad
Bheecarry, Ambicadutt
Mauritius, Port Louis
Ministry of Health and Quality of Life
Zumbo, Betty
France
Agence Régionale de Santé Ars Océan Indien
Weill, Mylène G.
France, Montpellier
Institut Des Sciences de L’evolution de Montpellier
Duron, Olivier
France, Montpellier
Institut Des Sciences de L’evolution de Montpellier
Statistics
Citations: 79
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pntd.0001440
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Cancer
Health System And Policy
Study Locations
Mauritius
Participants Gender
Female