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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
Nature Genetics, Volume 45, No. 6, Year 2013
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Description
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. © 2013 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Monda, Keri L.
United States, Thousand Oaks
Amgen Incorporated
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Chen, Gary K.
United States, Los Angeles
Keck School of Medicine of Usc
Taylor, Kira C.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Louisville
University of Louisville
Palmer, Cameron D.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
Edwards, Todd L.
United States, Nashville
Vanderbilt University Medical Center
Lange, Leslie A.
United States, Chapel Hill
Unc School of Medicine
Ng, Maggie Chor Yin
United States, Winston Salem
Wake Forest University School of Medicine
Adeyemo, Adebowale A.
United States, Bethesda
National Human Genome Research Institute Nhgri
Allison, Matthew A.
United States, La Jolla
University of California, San Diego
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Chen, Guanjie
United States, Bethesda
National Human Genome Research Institute Nhgri
Graff, Misa E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Irvin, Marguerite Ryan
United States, Birmingham
The University of Alabama at Birmingham
Rhie, Suhnkyong
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Li, Guo
United States, Seattle
University of Washington School of Medicine
Liu, Yongmei
United States, Winston Salem
Wake Forest University School of Medicine
Liu, Youfang
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lu, Yingchang
United States, New York
Icahn School of Medicine at Mount Sinai
Nalls, Mike A.
United States, Bethesda
National Institute on Aging Nia
Sun, Yan V.
United States, Atlanta
Rollins School of Public Health
Wojczynski, Mary K.
United States, St. Louis
Washington University School of Medicine in St. Louis
Yanek, Lisa R.
United States, Baltimore
Johns Hopkins School of Medicine
Aldrich, Melinda C.
United States, Nashville
Vanderbilt University Medical Center
United States, Nashville
Vanderbilt-ingram Cancer Center
United States, Nashville
Vanderbilt University School of Medicine
Ademola, Adeyinka Francis
Nigeria, Ibadan
University of Ibadan
Amos, Christopher I.
United States, Houston
The University of Texas Md Anderson Cancer Center
United States, Hanover
Dartmouth College
Bandera, E. V.
United States, New Brunswick
Rutgers Cancer Institute of new Jersey
Bock, Cathryn Hufford
United States, Detroit
Wayne State University
Britton, Angela F.
United States, Bethesda
National Institute on Aging Nia
Broeckel, Ulrich
United States, Milwaukee
Medical College of Wisconsin
Cai, Qiuyin
United States, Nashville
Vanderbilt University Medical Center
United States, Nashville
Vanderbilt-ingram Cancer Center
Caporaso, Neil E.
United States, Rockville
National Cancer Institute Nci
Carlson, Christopher S.
United States, Seattle
Fred Hutchinson Cancer Research Center
Carpten, John David
United States, Phoenix
Translational Genomics Research Institute
Casey, Graham R.
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Chen, Weimin
United States, Charlottesville
University of Virginia School of Medicine
Chen, Fang
United States, Charlottesville
University of Virginia School of Medicine
Chen, Yii Der Ida
United States, Los Angeles
Cedars-sinai Medical Center
Chiang, Charleston W.K.
United States, Boston
Harvard Medical School
Coetzee, Gerhard A.
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Demerath, Ellen W.
United States, Minneapolis
School of Public Health
Deming-Halverson, Sandra L.
United States, Nashville
Vanderbilt University Medical Center
United States, Nashville
Vanderbilt-ingram Cancer Center
Driver, Ryan W.
United States, Kennesaw
American Cancer Society
Dubbert, Patricia M.
United States, Little Rock
Education and Clinical Center
United States, Little Rock
University of Arkansas for Medical Sciences
Feitosa, Mary Furlan
United States, St. Louis
Washington University School of Medicine in St. Louis
Feng, Ye
United States, Los Angeles
Keck School of Medicine of Usc
Freedman, Barry I.
United States, Winston Salem
Wake Forest University School of Medicine
Gillanders, Elizabeth M.
United States, Rockville
National Cancer Institute Nci
Gottesman, Omri
United States, New York
Icahn School of Medicine at Mount Sinai
Guo, Xiuqing
United States, Los Angeles
Cedars-sinai Medical Center
Haritunians, Talin
United States, Los Angeles
Cedars-sinai Medical Center
Harris, Tamara B.
United States, Bethesda
National Institute on Aging Nia
Harris, Curtis C.A.
United States, Bethesda
National Institutes of Health Nih
Hennis, Anselm J.M.
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Jamaica, Kingston
The University of the West Indies
Barbados, Bridgetown
Ministry of Health Barbados
Hernandez, Dena G.
United States, Bethesda
National Institute on Aging Nia
McNeill, Lorna Haughton M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Howard, Timothy D.
United States, Winston Salem
Wake Forest University School of Medicine
Howard, Barbara V.
United States, Washington, D.c.
Medstar Health Research Institute
United States, Washington, D.c.
Georgetown-howard Universities Center for Clinical and Translational Science
Howard, Virginia J.
United States, Birmingham
The University of Alabama at Birmingham
Johnson, Karen C.
United States, Memphis
University of Tennessee Health Science Center
Kang, Sunjung
United States, New York
Suny Downstate Health Sciences University
Keating, Brendan J.
United States, Philadelphia
University of Pennsylvania
Kolb, Suzanne
United States, Seattle
Fred Hutchinson Cancer Research Center
Kuller, Lewis H.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Kutlar, Abdullah
United States, Augusta
Medical College of Georgia
Langefeld, Carl D.
United States, Winston Salem
Wake Forest University School of Medicine
Lettre, Guillaume
Canada, Montreal
Institut de Cardiologie de Montreal
Lohman, Kurt K.
United States, Winston Salem
Wake Forest University School of Medicine
Lotay, Vaneet S.
United States, New York
Icahn School of Medicine at Mount Sinai
Lyon, Helen N.
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Manson, Jo Ann E.
United States, Boston
Harvard Medical School
Maixner, William B.
United States, Chapel Hill
Unc-ch Adams School of Dentistry
Meng, Yan A.
United States, Cambridge
Massachusetts Institute of Technology
Monroe, Kristine R.
United States, Los Angeles
Keck School of Medicine of Usc
Morhason-Bello, Imran Oludare
Nigeria, Ibadan
University of Ibadan
Murphy, Adam Bryant
United States, Evanston
Northwestern University
Mychaleckyj, Josyf C.
United States, Charlottesville
University of Virginia School of Medicine
Nadukuru, Rajiv
United States, New York
Icahn School of Medicine at Mount Sinai
Nathanson, Katherine L.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Nayak, Uma
United States, Charlottesville
University of Virginia School of Medicine
N’Diaye, Amidou
United States, Boston
Boston Children's Hospital
Nemesure, Barbara Berger
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Wu, Suhyuh
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Leske, Maria Cristina
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Neslund-Dudas, Christine M.
United States, Detroit
Henry Ford Hospital
Neuhouser, Marian L.
United States, Seattle
Fred Hutchinson Cancer Research Center
Nyante, Sarah J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Ochs-Balcom, Heather M.
United States, Buffalo
University at Buffalo, the State University of new York
Ogunniyi, Adesola O.
Nigeria, Ibadan
University of Ibadan
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University of Ibadan
Ojengbede, Oladosu Akanbi
Nigeria, Ibadan
University of Ibadan
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Palmer, Julie R.P.
United States, Boston
Slone Epidemiology Center
Ruiz-Narváez, Edward A.
United States, Boston
Slone Epidemiology Center
Palmer, Nicholette (Nichole)
United States, Winston Salem
Wake Forest University School of Medicine
Press, Michael F.
United States, Los Angeles
Keck School of Medicine of Usc
Rampersaud, Evadnie
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Rasmussen-Torvik, Laura J.
United States, Chicago
Northwestern University Feinberg School of Medicine
Rodriguez-Gil, Jorge L.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
United States, Miami
Sylvester Comprehensive Cancer Center
Salako, Babatunde Lawal
Nigeria, Ibadan
University of Ibadan
Schadt, Eric E.
United States, New York
Icahn School of Medicine at Mount Sinai
Statistics
Citations: 245
Authors: 100
Affiliations: 60
Identifiers
Doi:
10.1038/ng.2608
ISSN:
10614036
e-ISSN:
15461718
Study Approach
Systematic review
Participants Gender
Male
Female