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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities
Hypertension, Volume 63, No. 5, Year 2014
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Description
White matter hyperintensities (WMH) are associated with hypertension. We examined interactions among blood pressure (BP), internal carotid artery (ICA) flow velocity parameters, and WMH. We obtained BP measurements from 694 community-dwelling subjects at mean ages 69.6 (±0.8) years and again at 72.6 (±0.7) years, plus brain MRI and ICA ultrasound at age 73±1 years. Diastolic and mean BP decreased and pulse pressure increased, but systolic BP did not change between 70 and 73 years. Multiple linear regression, corrected for vascular disease and risk factors, showed that WMH at the age of 73 years were associated with history of hypertension (β=0.13; P<0.001) and with BP at the age of 70 years (systolic β=0.08, mean β=0.09, diastolic β=0.08; all P<0.05); similar but attenuated associations were seen for BP at the age of 73 years. Lower diastolic BP and higher pulse pressure were associated with higher ICA pulsatility index at the age 73 years (diastolic BP age 70 years: standardized β=-0.24, P<0.001; pulse pressure age 70 years: β=0.19, P<0.001). WMH were associated with higher ICA pulsatility index (β=0.13; P=0.002) after adjusting for BP and correction for multiple testing. Therefore, falling diastolic BP and increased pulse pressure are associated with increased ICA pulsatility index, which in turn is associated with WMH. This suggests that hypertension and WMH may either associate indirectly because hypertension increases arterial stiffness that leads to WMH over time, or coassociate through advancing age and stiffer vessels, or both. Reducing vascular stiffness may reduce WMH progression and should be tested in randomized trials, in addition to testing antihypertensive therapy. © 2014 American Heart Association, Inc.
Authors & Co-Authors
Aribisala, Benjamin Segun
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Nigeria, Lagos
Lagos State University
Morris, Zoe
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Western General Hospital
Eadie, Elizabeth
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Western General Hospital
Thomas, Avril
United Kingdom, Edinburgh
Western General Hospital
Gow, Alan J.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Heriot-watt University
Valdés-Hernández, Maria Del Carmen
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Starr, John M.
United Kingdom, Edinburgh
The University of Edinburgh
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
United Kingdom, Edinburgh
Western General Hospital
Statistics
Citations: 126
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1161/HYPERTENSIONAHA.113.02735
ISSN:
0194911X
e-ISSN:
15244563
Research Areas
Noncommunicable Diseases