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AFRICAN RESEARCH NEXUS

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immunology and microbiology

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

Immunity, Volume 51, No. 1, Year 2019

The distinctions between inflammatory Th17 cells elicited by pathogens and tissue-resident homeostatic Th17 cells elicited by commensals are unclear. Omenetti et al. show that tissue-resident Th17 cells, in contrast to pathogen-elicited Th17 cells, exhibit little plasticity towards inflammatory cytokines, show muted metabolism, and do not participate in inflammatory reactions. These findings highlight the link between metabolic fitness and functional state.

Statistics
Citations: 205
Authors: 12
Affiliations: 3
Identifiers
Doi: 10.1016/j.immuni.2019.05.004
ISSN: 10747613
Research Areas
Noncommunicable Diseases

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