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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes
Rheumatology (United Kingdom), Volume 60, No. 2, Year 2021
Notification
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Description
Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- A nd older-onset patients are still incompletely understood. Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65 years or ≥65 years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results: A total of 1338 patients with AAV were included: 66% had disease onset at <65 years of age [female 50%; mean age 48.4 years (s.d. 12.6)] and 34% had disease onset at ≥65 years [female 54%; mean age 73.6 years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0.03]. Conclusion: Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients. © 2020 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Authors & Co-Authors
Monti, Sara
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Italy, Pavia
Università Degli Studi Di Pavia
Klersy, Catherine
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Montecucco, Carlomaurizio
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Caporali, R. Felice
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Alibaz-Oner, Fatma A.
Unknown Affiliation
Andrews, Jacqueline
Unknown Affiliation
Azevedo, E. Irene
Unknown Affiliation
Berger, Christoph Tobias
Unknown Affiliation
Bruce, Ian N.
Unknown Affiliation
Calabrese, Leonard H.
Unknown Affiliation
Cid, Maria C.
Unknown Affiliation
Conway, Richard P.
Unknown Affiliation
Daikeler, Thomas D.
Unknown Affiliation
Danda, Debashish
Unknown Affiliation
Dasgupta, Bhaskar
Unknown Affiliation
Diamantopoulos, Andreas P.
Unknown Affiliation
Direskeneli, Haner
Unknown Affiliation
da Fonseca, João Eurico Cabral
Unknown Affiliation
Gendi, Nagui S.T.
Unknown Affiliation
Grainger, Rebecca
Unknown Affiliation
Hammam, Nevin
Unknown Affiliation
Harigai, Masayoshi
Unknown Affiliation
Hatemi, Gulen
Unknown Affiliation
Henes, Jörg Christoph
Unknown Affiliation
Hess, Christoph
Unknown Affiliation
Hill, Catherine Louise
Unknown Affiliation
Hinojosa-Azaola, Andrea
Unknown Affiliation
Hocˇevar, Alojzija
Unknown Affiliation
Jayne, David R.W.
Unknown Affiliation
Kalyoncu, Umut
Unknown Affiliation
Khalidi, Nader A.
Unknown Affiliation
Kiliç, Levent
Unknown Affiliation
Kronbichler, Andreas
Unknown Affiliation
Lanyon, Peter Charles
Unknown Affiliation
MacKie, Sarah L.
Unknown Affiliation
Makol, Ashima
Unknown Affiliation
Matteson, Eric L.
Unknown Affiliation
McLaren, John Stuart
Unknown Affiliation
Moiseev, Sergey V.
Unknown Affiliation
Morgan, Ann W.
Unknown Affiliation
Muir, Alice
Unknown Affiliation
Mukhtyar, Chetan B.
Unknown Affiliation
Muratore, Francesco
Unknown Affiliation
Nordström, Dan C.E.
Unknown Affiliation
Novikov, Pavel I.
Unknown Affiliation
O'Donnell, John Liston
Unknown Affiliation
Pagnoux, Christian
Unknown Affiliation
Pereira, Liliana
Unknown Affiliation
Pettersson, Thomas E.
Unknown Affiliation
Prieto-González, Sergio
Unknown Affiliation
Putaala, Jukka
Unknown Affiliation
Robson, Joanna C.
Unknown Affiliation
Rodrigues, Miguel
Unknown Affiliation
Romão, Vasco C.
Unknown Affiliation
Sada, Ken Ei
Unknown Affiliation
Sahbudin, Ilfita
Unknown Affiliation
Salvarani, Carlo
Unknown Affiliation
Schmidt, Wolfgang A.
Unknown Affiliation
Shahin, Amira A.
Unknown Affiliation
Sharma, Aman K.
Unknown Affiliation
Song, Yeoungwook
Unknown Affiliation
Stamp, Lisa K.
Unknown Affiliation
Strbian, Daniel
Unknown Affiliation
Sunderkoẗter, Cord H.
Unknown Affiliation
Szekanecz, Zoltán A.
Unknown Affiliation
Sznajd, Jan
Unknown Affiliation
Tak, Paul Peter
Unknown Affiliation
Takeuchi, Tsutomu
Unknown Affiliation
Takizawa, Naoho
Unknown Affiliation
Tesarˇ, Vladimír
Unknown Affiliation
Tomŝiĉ, Matija
Unknown Affiliation
Toz, Bahtiyar
Unknown Affiliation
Wallace, Daniel J.
Unknown Affiliation
Watts, Richard A.
Unknown Affiliation
Wawrzycka-Adamczyk, Katarzyna
Unknown Affiliation
Weeratunga, Praveen Nilendra
Unknown Affiliation
Yoshida, Kazuki
Unknown Affiliation
Zayed, Hania Salah
Unknown Affiliation
Zhao, Minghui
Unknown Affiliation
Statistics
Citations: 19
Authors: 79
Affiliations: 5
Identifiers
Doi:
10.1093/rheumatology/keaa215
ISSN:
14620324
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Female