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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States
Nature Medicine, Volume 26, No. 6, Year 2020
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Description
Data on the detailed clinical progression of COVID-19 in conjunction with epidemiological and virological characteristics are limited. In this case series, we describe the first 12 US patients confirmed to have COVID-19 from 20 January to 5 February 2020, including 4 patients described previously1–3. Respiratory, stool, serum and urine specimens were submitted for SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) testing, viral culture and whole genome sequencing. Median age was 53 years (range: 21–68); 8 patients were male. Common symptoms at illness onset were cough (n = 8) and fever (n = 7). Patients had mild to moderately severe illness; seven were hospitalized and demonstrated clinical or laboratory signs of worsening during the second week of illness. No patients required mechanical ventilation and all recovered. All had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2–3 weeks after illness onset. Lowest real-time PCR with reverse transcription cycle threshold values in the upper respiratory tract were often detected in the first week and SARS-CoV-2 was cultured from early respiratory specimens. These data provide insight into the natural history of SARS-CoV-2. Although infectiousness is unclear, highest viral RNA levels were identified in the first week of illness. Clinicians should anticipate that some patients may worsen in the second week of illness. © 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
Authors & Co-Authors
Kujawski, Stephanie A.
United States, Atlanta
Centers for Disease Control and Prevention
Wong, Karen Kai Lun
United States, Atlanta
Centers for Disease Control and Prevention
Killerby, Marie E.
United States, Atlanta
Centers for Disease Control and Prevention
Midgley, Claire M.
United States, Atlanta
Centers for Disease Control and Prevention
Abedi, Glen R.
United States, Atlanta
Centers for Disease Control and Prevention
Barry, Vaughn
United States, Atlanta
Centers for Disease Control and Prevention
Beer, Karlyn D.
United States, Atlanta
Centers for Disease Control and Prevention
Biggs, Holly M.
United States, Atlanta
Centers for Disease Control and Prevention
Binder, Alison M.
United States, Atlanta
Centers for Disease Control and Prevention
Bozio, Catherine H.
United States, Atlanta
Centers for Disease Control and Prevention
Brown, Catherine M.
United States, Boston
Commonwealth of Massachusetts
Budd, Alicia P.
United States, Atlanta
Centers for Disease Control and Prevention
Cates, Jordan E.
United States, Atlanta
Centers for Disease Control and Prevention
Chatham-Stephens, Kevin
United States, Atlanta
Centers for Disease Control and Prevention
Chea, Nora
United States, Atlanta
Centers for Disease Control and Prevention
Chiou, Howard
United States, Los Angeles
Los Angeles County Department of Public Health
Curns, Aaron T.
United States, Atlanta
Centers for Disease Control and Prevention
Dawson, Patrick
United States, Atlanta
Centers for Disease Control and Prevention
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Feldstein, Leora R.
United States, Atlanta
Centers for Disease Control and Prevention
Fischer, Marc X.
United States, Atlanta
Centers for Disease Control and Prevention
Fry, Alicia M.
United States, Atlanta
Centers for Disease Control and Prevention
Gerber, Susan Ilene
United States, Atlanta
Centers for Disease Control and Prevention
Gounder, Prabhu P.
United States, Los Angeles
Los Angeles County Department of Public Health
Hall, Aron J.
United States, Atlanta
Centers for Disease Control and Prevention
Harcourt, Jennifer L.
United States, Atlanta
Centers for Disease Control and Prevention
Haynes, Amber K.
United States, Atlanta
Centers for Disease Control and Prevention
Hunter, Jennifer C.
United States, Atlanta
Centers for Disease Control and Prevention
Kamili, Shifaq
United States, Atlanta
Centers for Disease Control and Prevention
Kim, Lindsay
United States, Atlanta
Centers for Disease Control and Prevention
Kirking, Hannah L.
United States, Atlanta
Centers for Disease Control and Prevention
Layden, Jennifer E.
United States, Chicago
Chicago Department of Public Health
Li, Yan
United States, Atlanta
Centers for Disease Control and Prevention
Lindstrom, Stephen E.
United States, Atlanta
Centers for Disease Control and Prevention
Link-Gelles, Ruth
United States, Atlanta
Centers for Disease Control and Prevention
Lu, Xiaoyan
United States, Atlanta
Centers for Disease Control and Prevention
Madoff, Lawrence C.
United States, Boston
Commonwealth of Massachusetts
McClung, Nancy M.
United States, Atlanta
Centers for Disease Control and Prevention
McPherson, Tristan D.
United States, Chicago
Chicago Department of Public Health
United States, Atlanta
Centers for Disease Control and Prevention
Moon, Sungsil
United States, Atlanta
Centers for Disease Control and Prevention
Moro, Ruth N.
United States, Atlanta
Centers for Disease Control and Prevention
Murthy, Rekha K.
United States, Los Angeles
Cedars-sinai Medical Center
Novosad, Shannon A.
United States, Atlanta
Centers for Disease Control and Prevention
Paden, Clinton R.
United States, Atlanta
Centers for Disease Control and Prevention
Pallansch, Mark A.
United States, Atlanta
Centers for Disease Control and Prevention
Pillai, Satish K.
United States, Atlanta
Centers for Disease Control and Prevention
Pindyck, Talia N.
United States, Atlanta
Centers for Disease Control and Prevention
Pray, Ian W.
United States, Madison
Wisconsin Department of Health Services
United States, Atlanta
Centers for Disease Control and Prevention
Queen, Krista J.
United States, Atlanta
Centers for Disease Control and Prevention
Reese, Heather E.
United States, Atlanta
Centers for Disease Control and Prevention
Rha, Brian
United States, Atlanta
Centers for Disease Control and Prevention
Robinson, Philip A.
United States, Newport Beach
Hoag Memorial Hospital
Rolfes, Melissa A.R.
United States, Atlanta
Centers for Disease Control and Prevention
Routh, Janell A.
United States, Atlanta
Centers for Disease Control and Prevention
Sakthivel, Senthilkumar Kumar K.
United States, Atlanta
Centers for Disease Control and Prevention
Shetty, Varun U.
United States, Atlanta
Centers for Disease Control and Prevention
Tamin, Azaibi
United States, Atlanta
Centers for Disease Control and Prevention
Tao, Ying
United States, Atlanta
Centers for Disease Control and Prevention
Thornburg, Natalie J.
United States, Atlanta
Centers for Disease Control and Prevention
Tong, Suxiang Sue
United States, Atlanta
Centers for Disease Control and Prevention
Uehara, Anna
United States, Atlanta
Centers for Disease Control and Prevention
Uyeki, Timothy M.
United States, Atlanta
Centers for Disease Control and Prevention
Verani, Jennifer Rabke
United States, Atlanta
Centers for Disease Control and Prevention
Villarino, Elsa
Unknown Affiliation
Wang, Lijuan
United States, Atlanta
Centers for Disease Control and Prevention
Watson, John T.
United States, Atlanta
Centers for Disease Control and Prevention
Westercamp, Matthew D.
United States, Atlanta
Centers for Disease Control and Prevention
Whitaker, Brett L.
United States, Atlanta
Centers for Disease Control and Prevention
Wortham, Jonathan M.
United States, Atlanta
Centers for Disease Control and Prevention
Zhang, Jing
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 258
Authors: 70
Affiliations: 16
Identifiers
Doi:
10.1038/s41591-020-0877-5
ISSN:
10788956
Research Areas
Covid
Participants Gender
Male