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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
dentistry
Periodontal regeneration: potential role of bone morphogenetic proteins
Journal of Periodontal Research, Volume 29, No. 4, Year 1994
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Description
Initiation of osteogenesis and cementogenesis is a problem central to periodontal regeneration. A major advance in the understanding of bone formation has been the identification of an entirely new family of protein initiators, the bone morphogenetic proteins, that regulate cartilage and bone differentiation in vivo. The purification, genetic cloning and expression of recombinant human bone morphogenetic proteins (BMPs) have laid the foundation for the cellular and molecular dissection of bone development and regeneration. The striking evolutionary conservation of the BMP genes indicates that they are critical in the normal development and function of animals. In addition to postfetal osteogenesis, the BMPs may play multiple roles in embryonic development and organogenesis, including skeletogenesis and the development of craniofacial and dental tissues. The availability of recombinant human BMPs provides several challenges and opportunities to gain insights into the mechanisms regulating the regeneration of bone and cementum for optimal outcome in the periodontal patient. Copyright © 1994, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Ripamonti, Ugo
South Africa, Johannesburg
Mrc/wits Dental Research Institute
United States, Baltimore
Johns Hopkins School of Medicine
Reddi, A. Hari
South Africa, Johannesburg
Mrc/wits Dental Research Institute
United States, Baltimore
Johns Hopkins School of Medicine
Statistics
Citations: 161
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1111/j.1600-0765.1994.tb01216.x
ISSN:
00223484
e-ISSN:
16000765
Research Areas
Genetics And Genomics
Health System And Policy