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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Testicular toxicity of profenofos in matured male rats
Archives of Toxicology, Volume 81, No. 12, Year 2007
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Description
To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined, which revealed testicular destruction and degeneration represented by a layer of columnar epithelium, oedematous changes surrounding the seminiferous tubules besides vacuolated spermatogonial cells and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity. © 2007 Springer-Verlag.
Authors & Co-Authors
Moustafa, Gihan Gamal
Japan, Sapporo
Graduate School of Veterinary Medicine
Egypt, Zagazig
Faculty of Veterinary Medicine
Ibrahim, Zein Shabaan
Japan, Sapporo
Graduate School of Veterinary Medicine
Egypt, Tanta
Tanta University
Hashimoto, Y.
Japan, Sapporo
Graduate School of Veterinary Medicine
Alkelch, Alkelch M.
Egypt, Zagazig
Faculty of Veterinary Medicine
Sakamoto, Kentaro Q.
Japan, Sapporo
Graduate School of Veterinary Medicine
Ishizuka, Mayumi
Japan, Sapporo
Graduate School of Veterinary Medicine
Fujita, Shoichi
Japan, Sapporo
Graduate School of Veterinary Medicine
Statistics
Citations: 51
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1007/s00204-007-0217-2
ISSN:
03405761
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Participants Gender
Male