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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Postoperative and Pathological Outcomes of CROSS and FLOT as Neoadjuvant Therapy for Esophageal and Junctional Adenocarcinoma: An International Cohort Study From the Oesophagogastric Anastomosis Audit (OGAA)
Annals of Surgery, Volume 277, No. 5, Year 2023
Notification
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Description
Objective: This study aimed to compare the postoperative and pathological outcomes between carboplatin, paclitaxel, radiotherapy (CROSS) and 5-FU, leucovorine, oxaliplatin and docetaxel (FLOT) in esophageal adenocarcinoma (EAC) patients from an international, multicenter cohort. Summary of Background Data: Ongoing debate exists around optimum approach to locally advanced EAC, with proponents for perioperative chemotherapy, such as FLOT, or multimodal therapy, in particular the CROSS regimen. Methods: Patients undergoing CROSS (n = 350) and FLOT (n = 368), followed by curative esophagectomy for EAC were identified from the Oesophagogastric Anastomosis Audit. Results: The 90-day mortality was higher after CROSS than FLOT (5% vs 1%, P = 0.005), even on adjusted analyses [odds ratio (OR): 3.97, confidence interval (CI)95%: 1.34-13.67]. Postoperative mortality in CROSS were related to higher pulmonary (74% vs 60%) and cardiac complications (42% vs 20%) compared to FLOT. CROSS was associated with higher pathologic complete response (pCR) rates (18% vs 10%, P = 0.004) and margin-negative resections (93% vs 76%, P < 0.001) compared with FLOT. On adjusted analyses, CROSS was associated with higher pCR rates (OR: 2.05, CI95%: 1.26-3.34) and margin-negative resections (OR: 4.55, CI95%: 2.70-7.69) compared to FLOT. Conclusions: This study provides real-world data CROSS was associated with higher 90-day mortality than FLOT, related to cardio-pulmonary complications with CROSS. These warrant a further review into causes and mechanisms in selected patients, and at minimum suggest the need for strict radiation therapy quality assurance. Research into impact of higher pCR rates and R0 resections with CROSS compared to FLOT on long-term survival is needed. © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
Authors & Co-Authors
Alderson, Derek A.
Unknown Affiliation
Bundred, James R.
Unknown Affiliation
Gossage, James A.
Unknown Affiliation
Griffiths, Ewen A.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Jefferies, Benjamin
Unknown Affiliation
Kamarajah, Sivesh K.
Unknown Affiliation
Nepogodiev, Dmitri
Unknown Affiliation
Siaw-Acheampong, Kobby
Unknown Affiliation
Singh, Prashant Kumar
Unknown Affiliation
Vohra, Ravi S.
Unknown Affiliation
Wanigasooriya, Kasun
Unknown Affiliation
Whitehouse, Tony
Unknown Affiliation
Gjata, Arben
Unknown Affiliation
Moreno, Jorge I.
Unknown Affiliation
Takeda, Flavio Roberto
Unknown Affiliation
Kidane, Biniam
Unknown Affiliation
Guevara Castro, R.
Unknown Affiliation
Harustiak, Tomas
Unknown Affiliation
Bekele, Abebe
Unknown Affiliation
Kechagias, Aristotelis
Unknown Affiliation
Kennedy, Andrew D.M.
Unknown Affiliation
Da Roit, Anna
Unknown Affiliation
Bagajevas, Aleksandras
Unknown Affiliation
Azagra, Juan Santiago
Unknown Affiliation
Mahendran, Hans Alexander
Unknown Affiliation
Mejía-Fernández, Lorelí
Unknown Affiliation
Wijnhoven, Bas P.L.
Unknown Affiliation
El-Kafsi, Jihène A.
Unknown Affiliation
Sayyed, Raza Hasnain
Unknown Affiliation
Sousa, Mariana
Unknown Affiliation
Sampaio, A. S.
Unknown Affiliation
Blanco, Ruth
Unknown Affiliation
Wallner, Bengt
Unknown Affiliation
Schneider, Paul Magnus
Unknown Affiliation
Hsu, Pokuei
Unknown Affiliation
Isik, Arda A.
Unknown Affiliation
Gananadha, Sivakumar
Unknown Affiliation
Devadas, Michael
Unknown Affiliation
Duong, Cuong P.
Unknown Affiliation
Talbot, Michael
Unknown Affiliation
Hii, Michael Wei J.
Unknown Affiliation
Jacobs, Rod
Unknown Affiliation
Andreollo, N. A.
Unknown Affiliation
Johnston, Brian R.
Unknown Affiliation
Darling, Gail Elizabeth
Unknown Affiliation
Isaza-Restrepo, Andrés
Unknown Affiliation
Rosero, Germán
Unknown Affiliation
Arias-Amézquita, Fernando
Unknown Affiliation
Raptis, Dimitrios Aristotle
Unknown Affiliation
Gaedcke, Jochen
Unknown Affiliation
Reim, Daniel
Unknown Affiliation
Izbicki, Jakob Robert
Unknown Affiliation
Egberts, Jan Hendrik
Unknown Affiliation
Dikinis, Sarunas
Unknown Affiliation
Kjaer, Daniel Willy
Unknown Affiliation
Larsen, Michael Hareskov
Unknown Affiliation
Achiam, Michael Patrick
Unknown Affiliation
Saarnio, Juha
Unknown Affiliation
Theodorou, Dimitrios A.
Unknown Affiliation
Liakakos, Theodore D.
Unknown Affiliation
Korkolis, Dimitrios P.
Unknown Affiliation
Robb, William B.
Unknown Affiliation
Murphy, Thomas James
Unknown Affiliation
Reynolds, John Vincent
Unknown Affiliation
Bonavina, Luigi
Unknown Affiliation
Valmasoni, Michele
Unknown Affiliation
Bardini, Romeo
Unknown Affiliation
Weindelmayer, Jacopo
Unknown Affiliation
Terashima, Masanori
Unknown Affiliation
White, Russell E.
Unknown Affiliation
AlGhunaim, Essa M.
Unknown Affiliation
Elhadi, Muhammed K.
Unknown Affiliation
León-Takahashi, Alberto Mitsuo
Unknown Affiliation
Medina-Franco, H.
Unknown Affiliation
Lau, P. C.
Unknown Affiliation
Okonta, Kelechi Emmanuel
Unknown Affiliation
Heisterkamp, Joos
Unknown Affiliation
Rosman, Camiel
Unknown Affiliation
van Hillegersberg, Richard
Unknown Affiliation
Beban, Grant R.
Unknown Affiliation
Babor, Richard
Unknown Affiliation
Gordon, Alexandra C.
Unknown Affiliation
Rossaak, Jeremy I.
Unknown Affiliation
Pal, Khawaja Muhammad Inam
Unknown Affiliation
Naqi, Syed Asghar
Unknown Affiliation
Syed, Aamir Ali
Unknown Affiliation
Barbosa, José Adelino Lobarinhas
Unknown Affiliation
Vicente, Carla Sofia
Unknown Affiliation
Leite, Júlio Soares
Unknown Affiliation
Freire, Jose
Unknown Affiliation
Casaca, Rui
Unknown Affiliation
Costa, Rita C.T.
Unknown Affiliation
Scurtu, Radu Razvan
Unknown Affiliation
Mogoanta, Stelian Ştefǎniţǎ
Unknown Affiliation
So, Jimmy By
Unknown Affiliation
Loureiro, Carlos Manoel Bulcão
Unknown Affiliation
Pera, Manuel
Unknown Affiliation
Guner, Ali
Unknown Affiliation
Çolak, Elif F.
Unknown Affiliation
Jain, Prashant K.
Unknown Affiliation
Higgs, Simon M.
Unknown Affiliation
Viswanath, Yirupaiahgari Krishnaiah Setty
Unknown Affiliation
Turner, Paul D.
Unknown Affiliation
Boddy, Alexander P.
Unknown Affiliation
Allum, William H.
Unknown Affiliation
Cheong, Edward C.K.
Unknown Affiliation
Maynard, Nick David
Unknown Affiliation
Berrisford, Richard George
Unknown Affiliation
Underwood, Tim James
Unknown Affiliation
Al-Bahrani, Ahmed Z.
Unknown Affiliation
Thomas, Mathew
Unknown Affiliation
Fergusson, James
Unknown Affiliation
Beenen, Edwin
Unknown Affiliation
Mosse, Charles S.
Unknown Affiliation
Salim, J.
Unknown Affiliation
Cheah, Sheryn
Unknown Affiliation
Wright, Timothy
Unknown Affiliation
Cerdeira, Marisol Perez
Unknown Affiliation
McQuillan, Patrick W.
Unknown Affiliation
Richardson, Martin
Unknown Affiliation
Liem, H.
Unknown Affiliation
Spillane, John B.
Unknown Affiliation
Yacob, M.
Unknown Affiliation
Albadawi, F.
Unknown Affiliation
Thorpe, Tina
Unknown Affiliation
Dingle, A.
Unknown Affiliation
Cabalag, Carlos Suhady
Unknown Affiliation
Loi, K.
Unknown Affiliation
Fisher, Oliver M.
Unknown Affiliation
Ward, Salena M.
Unknown Affiliation
Read, Matthew D.
Unknown Affiliation
Johnson, Mary Ann
Unknown Affiliation
Bassari, R.
Unknown Affiliation
Bui, H.
Unknown Affiliation
da Rocha, Júlio Rafael Mariano
Unknown Affiliation
Lopes, Luiz Roberto
Unknown Affiliation
Tercioti, Valdir
Unknown Affiliation
Ferrer, José Antônio Possatto
Unknown Affiliation
Buduhan, G.
Unknown Affiliation
Tan, Lijie
Unknown Affiliation
Srinathan, Sadeesh K.
Unknown Affiliation
Shea, Patricia
Unknown Affiliation
Yeung, Jonathan C.
Unknown Affiliation
Allison, Frances
Unknown Affiliation
Carroll, Paul A.
Unknown Affiliation
Vargas-Barato, Felipe
Unknown Affiliation
Gonzalez, Freddy
Unknown Affiliation
Ortega, Jairo
Unknown Affiliation
Nega, Berhanu
Unknown Affiliation
Tizazu, Ayalew
Unknown Affiliation
Kauppila, Joonas H.
Unknown Affiliation
Kreuser, Nicole
Unknown Affiliation
Schizas, Dimitrios N.
Unknown Affiliation
Charalabopoulos, Alexandros
Unknown Affiliation
Manatakis, Dimitrios K.
Unknown Affiliation
Balalis, Dimitrios
Unknown Affiliation
Bolger, Jarlath Christopher
Unknown Affiliation
Quinn, Alanna Jane
Unknown Affiliation
Dé Manzoni, Giovanni D.
Unknown Affiliation
Mwachiro, Michael M.
Unknown Affiliation
Odera, Agneta
Unknown Affiliation
Mwachiro, Elizabeth B.
Unknown Affiliation
AlShehab, Derar S.A.
Unknown Affiliation
Elhadi, Ahmed
Unknown Affiliation
Lagarde, Sjoerd M.
Unknown Affiliation
van Lanschot, Joseph Jan Baptist
Unknown Affiliation
Bouwense, Stefan A.W.
Unknown Affiliation
Ruurda, Jelle P.
Unknown Affiliation
Ekwunife, Christopher Nonso
Unknown Affiliation
Sarwar, Muhammad Zeeshan
Unknown Affiliation
Shakeel, Osama
Unknown Affiliation
Khattak, Shahid
Unknown Affiliation
Ahmed, Hazem H.
Unknown Affiliation
Campos, José C.
Unknown Affiliation
Beuran, Mircea
Unknown Affiliation
Shabbir, Asim
Unknown Affiliation
Rutegård, Martin
Unknown Affiliation
Er, Sadettin
Unknown Affiliation
Yildirim, Reyyan
Unknown Affiliation
Baki, Bahadir Emre
Unknown Affiliation
Akkapulu, Nezih
Unknown Affiliation
Hardwick, Richard Henry
Unknown Affiliation
Wiggins, Tom H.
Unknown Affiliation
Wilson, Iain H.
Unknown Affiliation
Blencowe, Natalie S.
Unknown Affiliation
Byrne, Benjamin E.
Unknown Affiliation
Koshy, Renol Mathew
Unknown Affiliation
Worku, Dawit G.
Unknown Affiliation
MacDonald, Andrew
Unknown Affiliation
Dwerryhouse, Simon J.
Unknown Affiliation
Hornby, Steven T.
Unknown Affiliation
Wadley, Martin Stuart
Unknown Affiliation
Baker, Cara R.
Unknown Affiliation
Kelly, Mark
Unknown Affiliation
Davies, Andrew R.
Unknown Affiliation
Di Maggio, Francesco
Unknown Affiliation
McKay, Siobhan Chloe
Unknown Affiliation
Singhal, Rishi
Unknown Affiliation
Tucker, Olga N.
Unknown Affiliation
Verma, Rajat R.
Unknown Affiliation
Sarela, Abeezar Ismail
Unknown Affiliation
Sue-Ling, Henry M.
Unknown Affiliation
Butt, Zahid A.
Unknown Affiliation
Ahmed, Ahmed Rashid
Unknown Affiliation
Kumar, Sacheen
Unknown Affiliation
Chaudry, Asif M.
Unknown Affiliation
Evans, Richard P.T.
Unknown Affiliation
Zanotti, Daniela
Unknown Affiliation
Sgromo, Bruno
Unknown Affiliation
Carter, Nicholas C.
Unknown Affiliation
Abdulrahman, Muammar
Unknown Affiliation
Ackroyd, Roger
Unknown Affiliation
Patel, Krashna
Unknown Affiliation
Makey, Ian A.
Unknown Affiliation
Weyant, Michael John
Unknown Affiliation
Statistics
Citations: 11
Authors: 215
Affiliations: 1
Identifiers
Doi:
10.1097/SLA.0000000000005394
ISSN:
00034932
Research Areas
Cancer
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative