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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The diversity of meningococcal carriage across the African meningitis belt and the impact of vaccination with a group a meningococcal conjugate vaccine
Journal of Infectious Diseases, Volume 212, No. 8, Year 2015
Notification
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Description
Background.Study of meningococcal carriage is essential to understanding the epidemiology of Neisseria meningitidis infection. Methods.Twenty cross-sectional carriage surveys were conducted in 7 countries in the African meningitis belt; 5 surveys were conducted after introduction of a new serogroup A meningococcal conjugate vaccine (MenAfriVac). Pharyngeal swab specimens were collected, and Neisseria species were identified by microbiological and molecular techniques. Results.A total of 1687 of 48 490 participants (3.4%; 95% confidence interval [CI], 3.2%-3.6%) carried meningococci. Carriage was more frequent in individuals aged 5-14 years, relative to those aged 15-29 years (adjusted odds ratio [OR], 1.41; 95% CI, 1.25-1.60); in males, relative to females (adjusted OR, 1.17; 95% CI, 1.10-1.24); in individuals in rural areas, relative to those in urban areas (adjusted OR, 1.44; 95% CI, 1.28-1.63); and in the dry season, relative to the rainy season (adjusted OR, 1.54; 95% CI, 1.37-1.75). Forty-eight percent of isolates had genes encoding disease-associated polysaccharide capsules; genogroup W predominated, and genogroup A was rare. Strain diversity was lower in countries in the center of the meningitis belt than in Senegal or Ethiopia. The prevalence of genogroup A fell from 0.7% to 0.02% in Chad following mass vaccination with MenAfriVac. Conclusions.The prevalence of meningococcal carriage in the African meningitis belt is lower than in industrialized countries and is very diverse and dynamic, even in the absence of vaccination. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4577048/bin/supp_212_8_1298__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4577048/bin/supp_jiv211_jiv211supp.docx
Authors & Co-Authors
Ali, Oumer A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Aseffa, Abraham
United Kingdom, London
London School of Hygiene & Tropical Medicine
Bedru, Ahmed
United Kingdom, London
London School of Hygiene & Tropical Medicine
Lema, Tsehaynesh
United Kingdom, London
London School of Hygiene & Tropical Medicine
Moti, Tesfaye
United Kingdom, London
London School of Hygiene & Tropical Medicine
Tekletsion, Yenenesh K.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Worku, Alemayehu Gebeyehu
United Kingdom, London
London School of Hygiene & Tropical Medicine
Xabher, Haimanot Guebre
United Kingdom, London
London School of Hygiene & Tropical Medicine
Yamuah, Lawrence K.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Boukary, Rahamatou Moustapha
United Kingdom, London
London School of Hygiene & Tropical Medicine
Collard, Jean Marc
United Kingdom, London
London School of Hygiene & Tropical Medicine
Dano, Ibrahim Dan
United Kingdom, London
London School of Hygiene & Tropical Medicine
Habiboulaye, Ibrahim
United Kingdom, London
London School of Hygiene & Tropical Medicine
Issaka, Bassira Boubacar
United Kingdom, London
London School of Hygiene & Tropical Medicine
Jusot, Jean François
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ousmane, Sani
United Kingdom, London
London School of Hygiene & Tropical Medicine
Rabe, Issoufa
United Kingdom, London
London School of Hygiene & Tropical Medicine
Daugla, Doumagoum Moto
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gami, Jean Pierre
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gamougam, Kadidja
United Kingdom, London
London School of Hygiene & Tropical Medicine
Mbainadji, Lodoum
United Kingdom, London
London School of Hygiene & Tropical Medicine
Naïbeï, Nathan
United Kingdom, London
London School of Hygiene & Tropical Medicine
Narbé, Maxime
United Kingdom, London
London School of Hygiene & Tropical Medicine
Toralta, Jacques
United Kingdom, London
London School of Hygiene & Tropical Medicine
Berthe, Abdoulaye
United Kingdom, London
London School of Hygiene & Tropical Medicine
Diallo, Kanny
United Kingdom, London
London School of Hygiene & Tropical Medicine
Keita, Mahamadou Minamba
United Kingdom, London
London School of Hygiene & Tropical Medicine
Onwuchekwa, Uma U.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Sow, Samba Ousmane
United Kingdom, London
London School of Hygiene & Tropical Medicine
Tamboura, Boubou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Traoré, Awa C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Touré, Aliou Y.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Clark, Thomas A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Mayer, Leonard W.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Amodu, Mary O.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Beida, Omeiza
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gadzama, Galadima Bala
United Kingdom, London
London School of Hygiene & Tropical Medicine
Omotara, Babatunji Abayomi
United Kingdom, London
London School of Hygiene & Tropical Medicine
Sambo, Zailani B.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Yahya, Shuaibu
United Kingdom, London
London School of Hygiene & Tropical Medicine
Chandramohan, Daniel
United Kingdom, London
London School of Hygiene & Tropical Medicine
Greenwood, Brian M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hassan-King, Musa K.A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Manigart, Olivier
United Kingdom, London
London School of Hygiene & Tropical Medicine
Stuart, James Mac Naughton
United Kingdom, London
London School of Hygiene & Tropical Medicine
Woukeu, Arouna
United Kingdom, London
London School of Hygiene & Tropical Medicine
Basta, Nicole E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Bai, Xilian
United Kingdom, London
London School of Hygiene & Tropical Medicine
Borrow, Ray
United Kingdom, London
London School of Hygiene & Tropical Medicine
Findlow, Helen
United Kingdom, London
London School of Hygiene & Tropical Medicine
Alavo, Serge
United Kingdom, London
London School of Hygiene & Tropical Medicine
Basséne, Hubert
United Kingdom, London
London School of Hygiene & Tropical Medicine
Diallo, Aldiouma M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Dieng, Mariétou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Doucouré, Souleymane
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gomis, Jules François
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ndiaye, Assane R.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Sokhna, Cheikh Sadibou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Trape, Jean François
United Kingdom, London
London School of Hygiene & Tropical Medicine
Akalifa, Bugri G.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Forgor, Abudulai Adams
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hodgson, Abraham V.O.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Osei, Isaac
United Kingdom, London
London School of Hygiene & Tropical Medicine
Quaye, Stephen Laryea
United Kingdom, London
London School of Hygiene & Tropical Medicine
Williams, John Kino
United Kingdom, London
London School of Hygiene & Tropical Medicine
Wontuo, Peter
United Kingdom, London
London School of Hygiene & Tropical Medicine
Irving, Thomas J.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Trotter, Caroline
United Kingdom, London
London School of Hygiene & Tropical Medicine
Bennett, Julia S.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hill, Dorothea M.C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Harrison, Odile Barbara
United Kingdom, London
London School of Hygiene & Tropical Medicine
Maiden, Martin Christopher James
United Kingdom, London
London School of Hygiene & Tropical Medicine
Rebbetts, Lisa S.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Watkins, Eleanor Rose
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 61
Authors: 74
Affiliations: 1
Identifiers
Doi:
10.1093/infdis/jiv211
ISSN:
00221899
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Chad
Ethiopia
Senegal
Participants Gender
Female