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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and characteristics of prostate cancer among participants of a communitybased screening in Nigeria using serum prostate specific antigen and digital rectal examination
Pan African Medical Journal, Volume 15, Article 129, Year 2013
Notification
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Description
Introduction: Prostate cancer (CaP) is the most commonly diagnosed cancer among Nigerian men but CaP screening is not a common practice. The true burden of the disease in Nigeria is not known. The study was aimed at studying the community burden of CaP in Lagos. Methods: During a community-based prostate cancer awareness program in 13 local government areas of Lagos, men aged >40 years had serum total PSA (tPSA) test and digital rectal examination (DRE). Those with abnormal DRE or tPSA >95th percentile of the cohort or both were selected for prostate biopsy (TRPB). Results: 4172 men were screened and complete data was available for 4110 (98.5%). The mean age was 60.8 years. DRE was abnormal in 410 men and was significantly correlated with the age of the patient and tPSA (p<0.001). The tPSA ranged from 0 to 438.3ng/ml with a median, mean and 95th percentile of 1.5, 2.5 and 10.0ng/ml respectively. 341 out of the 438(78%) men selected were subjected to TRBP. Forty-three men had histological diagnosis of CaP, giving an estimated prevalence rate of at least 1.046% or 1046 per 100,000 men of age ≥40. Only 11 (26%) had organ-confined disease while 17 (40%) had locally advanced disease and 15 (35%) men had metastatic disease. The majority of the men, 32 (74%) were reported to have Gleason's score of ≥7. Conclusion: The prevalence rate of CaP among men aged ≥40 years in Lagos is higher than previously reported in hospital-based study. Majority have advanced and high-grade disease. © Dr Stephen Odunayo Ikuerowo et al.
Authors & Co-Authors
Ikuerowo, Stephen Odunayo
Nigeria, Lagos
Lagos State University
Omisanjo, Olufunmilade Akinfolarin
Nigeria, Lagos
Lagos State University
Bioku, Muftau Jimoh
Nigeria, Lagos
Lagos State University
Ajala, Michael Olawale
Nigeria, Lagos
General Hospital
Nonyelim Mordi, Victor Patrick
Nigeria, Lagos
Lagos State University
Esho, Julius Olusanmi
Nigeria, Lagos
Lagos State University
Statistics
Citations: 65
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.11604/pamj.2013.15.129.2489
ISSN:
19378688
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Nigeria
Participants Gender
Male