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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces
Journal of Virology, Volume 84, No. 4, Year 2010
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Description
Circoviruses are known to infect birds and pigs and can cause a wide range of severe symptoms with significant economic impact. Using viral metagenomics, we identified circovirus-like DNA sequences and characterized 15 circular viral DNA genomes in stool samples from humans in Pakistan, Nigeria, Tunisia, and the United States and from wild chimpanzees. Distinct genomic features and phylogenetic analysis indicate that some viral genomes were part of a previously unrecognized genus in the Circoviridae family we tentatively named "Cyclovirus" whose genetic diversity is comparable to that of all the known species in the Circovirus genus. Circoviridae detection in the stools of U.S. adults was limited to porcine circoviruses which were also found in most U.S. pork products. To determine whether the divergent cycloviruses found in non-U.S. human stools were of dietary origin, we genetically compared them to the cycloviruses in muscle tissue samples of commonly eaten farm animals in Pakistan and Nigeria. Limited genetic overlap between cycloviruses in human stool samples and local cow, goat, sheep, camel, and chicken meat samples indicated that the majority of the 25 Cyclovirus species identified might be human viruses. We show that the genetic diversity of small circular DNA viral genomes in various mammals, including humans, is significantly larger than previously recognized, and frequent exposure through meat consumption and contact with animal or human feces provides ample opportunities for cyclovirus transmission. Determining the role of cycloviruses, found in 7 to 17% of non-U.S. human stools and 3 to 55% of non-U.S. meat samples tested, in both human and animal diseases is now facilitated by knowledge of their genomes. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2812408/bin/supp_84_4_1674__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2812408/bin/supp_84_4_1674__Supplementary_Table_and_Figure.zip
Authors & Co-Authors
Li, Linlin
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Kapoor, Amit
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Slikas, Beth
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Bamidele, Oderinde Soji
Nigeria, Maiduguri
University of Maiduguri
Wang, Chunlin
United States, Stanford
Stanford University School of Medicine
Shaukat, Shahzad
Pakistan, Islamabad
National Institute of Health Pakistan
Masroor, Muhammad Alam
Pakistan, Islamabad
National Institute of Health Pakistan
Wilson, Michael L.
United States, Minneapolis
University of Minnesota Twin Cities
Ndjango, Jean Bosco N.
Democratic Republic Congo, Kisangani
Université de Kisangani
Peeters, Martine F.
France, Montpellier
Ird Centre de Montpellier
Gross-Camp, Nicole D.
United Kingdom, Norwich
University of East Anglia
Muller, Martin N.
United States, Albuquerque
The University of new Mexico
Hahn, Beatrice H.
United States, Birmingham
The University of Alabama at Birmingham
Wolfe, Nathan D.
United States, Palo Alto
Stanford University
United States, San Francisco
Global Viral Forecasting Initiative
Triki, Henda
Tunisia, Tunis
Institut Pasteur de Tunis
Bartkus, Joanne
United States, Saint Paul
Minnesota Department of Health
Zaidi, Syed Sohail Zahoor
Pakistan, Islamabad
National Institute of Health Pakistan
Delwart, E. L.
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 343
Authors: 18
Affiliations: 15
Identifiers
Doi:
10.1128/JVI.02109-09
ISSN:
0022538X
Research Areas
Genetics And Genomics
Study Locations
Nigeria
Tunisia