Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
No virological failure in semen during properly suppressive antiretroviral therapy despite subtherapeutic local drug concentrations
HIV Clinical Trials, Volume 7, No. 6, Year 2006
Notification
URL copied to clipboard!
Description
Purpose: The aim of the study was to investigate whether drug resistance occurs earlier in seminal than in blood plasma with the use of such HAART regimens, of which only the two NRTIs achieve therapeutic concentrations in seminal plasma. Method: Seminal and blood plasma of 12 patients, for 48-96 weeks on suppressive first-line therapy with saquinavir/ritonavir/didanosine/ lamivudine, nelfinavir/didanosine/stavudine, or efavirenz/lamivudine/ zidovudine were prospectively evaluated for HIV-1-RNA resistance mutations and drug concentrations. Results: Saquinavir, nelfinavir, and efavirenz blood plasma concentrations were in the therapeutic range. Nelfinavir and efavirenz seminal plasma concentrations were below the limit of quantification. In only 2 of 9 seminal plasma samples, from 1 of 6 patients, the saquinavir concentration was above the minimum therapeutic level. The seminal plasma HIV-1-RNA concentration remained undetectable in all patients up to 96 weeks, and therefore drug resistance could not be demonstrated. Thus, despite suboptimal local drug concentrations, no virological failure occurred in seminal plasma after prolonged first-line HAART. Conclusion: This finding supports the hypothesis that the source of HIV in semen is a spillover from the blood/extraluminal tissue and that therefore seminal plasma drug levels may not be critical for viral suppression within the lumen of the male genital tract. © 2006 Thomas Land Publishers, Inc.
Authors & Co-Authors
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Droste, Jacqueline A.H.
Netherlands, Nijmegen
Radboud University Medical Center
Jurriaans, Suzanne
Netherlands, Amsterdam
Universiteit Van Amsterdam
Burger, David M.
Netherlands, Nijmegen
Radboud University Medical Center
Borleffs, Jan C.C.
Netherlands, Utrecht
University Medical Center Utrecht
Lange, Joep M.A.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
International Antiviral Therapy Evaluation Center
Prins, Jan M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 16
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1310/hct0706-285
ISSN:
15284336
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Male