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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: Results of an international multi-centre study
Age and Ageing, Volume 50, No. 3, Year 2021
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Description
Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54 83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18 49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54 5.02), frailty (CFS 8 versus 1 3: HR 3.03, CI 2.29 4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1 3: odds ratio 7.00, CI 5.27 9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge.The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age. © 2021 Oxford University Press. All rights reserved.
Authors & Co-Authors
Welch, Carly
United Kingdom, Birmingham
University of Birmingham
Elhadi, Muhammed K.
Unknown Affiliation
Jackson, Thomas A.
Unknown Affiliation
Magill, Laura
Unknown Affiliation
Masoli, Jane A.H.
Unknown Affiliation
Nirantharakumar, Krishnarajah
Unknown Affiliation
Perry, Rita J.
Unknown Affiliation
Pettitt, Michala E.
Unknown Affiliation
Pinkney, Thomas D.
Unknown Affiliation
Quinn, Terence J.
Unknown Affiliation
Steves, Claire J.
Unknown Affiliation
Witham, M. D.
Unknown Affiliation
Abdelhafez, Mohammed H.
Unknown Affiliation
Abdelwahab, Omar Ahmed
Unknown Affiliation
Abdulhadi, Osama M.A.S.
Unknown Affiliation
Baili, Efstratia
Unknown Affiliation
Barra, Fabio
Unknown Affiliation
Bayhan, Zülfü
Unknown Affiliation
Boden, Regan
Unknown Affiliation
Bouhuwaish, Ahmad
Unknown Affiliation
Brachini, Gioia
Unknown Affiliation
Cąpoglu, Recayi
Unknown Affiliation
Ceccarelli, Giancarlo
Unknown Affiliation
Charalabopoulos, Alexandros
Unknown Affiliation
Cicerchia, Pierfranco Maria
Unknown Affiliation
Cordie, Ahmed Abdelmonem
Unknown Affiliation
Dotchin, Catherine Louise
Unknown Affiliation
Elghazaly, Shrouk Mahmoud
Unknown Affiliation
Elmehrath, Ahmed O.
Unknown Affiliation
Etchill, Eric Wayne
Unknown Affiliation
Gallo, Gaetano
Unknown Affiliation
Gerretsen, Hannah E.
Unknown Affiliation
Gönüllü, Emre
Unknown Affiliation
Hadreiez, Ahmed Khalifa M.
Unknown Affiliation
Hajiioannou, Jiannis K.
Unknown Affiliation
Haut, Elliott R.
Unknown Affiliation
Heinsohn, Torben
Unknown Affiliation
Hetta, Helal F.
Unknown Affiliation
Jackson, Karl A.
Unknown Affiliation
Khan, Muhammad Shahzeb H.
Unknown Affiliation
Lapolla, Pierfrancesco
Unknown Affiliation
Mantoǧlu, Barış
Unknown Affiliation
Mingoli, Andrea
Unknown Affiliation
Moustafa, Mohamed Ma
Unknown Affiliation
Perra, Teresa
Unknown Affiliation
Porcu, Alberto
Unknown Affiliation
Rapaport, Sarah F.
Unknown Affiliation
Saad, Mahmoud M.
Unknown Affiliation
Shaban, Mosab Abdelrazak A.
Unknown Affiliation
Stevens, Kent A.
Unknown Affiliation
Vervoort, Dominique V.
Unknown Affiliation
Statistics
Citations: 104
Authors: 51
Affiliations: 1
Identifiers
Doi:
10.1093/ageing/afab026
ISSN:
00020729
Research Areas
Cancer
Covid
Environmental
Mental Health
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative
Participants Gender
Male