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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4
+
T-Cells and CCR5 expression in the female genital tract
PLoS ONE, Volume 9, No. 6, Article e98593, Year 2014
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Description
Background: Schistosoma haematobium is a waterborne parasite that may cause female genital schistosomiasis (FGS), characterized by genital mucosal lesions. There is clinical and epidemiological evidence for a relationship between FGS and HIV. We investigated the impact of FGS on HIV target cell density and expression of the HIV co-receptor CCR5 in blood and cervical cytobrush samples. Furthermore we evaluated the effect of anti-schistosomal treatment on these cell populations. Design: The study followed a case-control design with post treatment follow-up, nested in an on-going field study on FGS. Methods: Blood and cervical cytobrush samples were collected from FGS negative and positive women for flow cytometry analyses. Urine samples were investigated for schistosome ova by microscopy and polymerase chain reaction (PCR). Results: FGS was associated with a higher frequency of CD14+ cells (monocytes) in blood (11.5% in FGS+ vs. 2.2% in FGS-, p = 0.042). Frequencies of CD4 + cells expressing CCR5 were higher in blood samples from FGS+ than from FGS- women (4.7% vs. 1.5%, p = 0.018). The CD14+ cell population decreased significantly in both compartments after anti-schistosomal treatment (p = 0.043). Although the frequency of CD4+ cells did not change after treatment, frequencies of CCR5 expression by CD4+ cells decreased significantly in both compartments (from 3.4% to 0.5% in blood, p = 0.036; and from 42.4% to 5.6% in genital samples, p = 0.025). Conclusions: The results support the hypothesis that FGS may increase the risk of HIV acquisition, not only through damage of the mucosal epithelial barrier, but also by affecting HIV target cell populations, and that anti-schistosomal treatment can modify this. © 2014 Kleppa et al.
Authors & Co-Authors
Kleppa, Elisabeth
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Medisinske Fakultet
Ramsuran, Veron
South Africa, Durban
The Nelson R. Mandela Medical School
Zulu, Siphosenkosi Gift
South Africa, Durban
The Nelson R. Mandela Medical School
Karlsen, Gunn Hege
Denmark, Aarhus
Aarhus Universitet
Bere, Alfred
United States, Atlanta
Emory University
Passmore, Jo Ann Shelley
South Africa, Cape Town
University of Cape Town
Ndhlovu, Patricia Doris
United Kingdom, London
Imperial College London
Lillebø, Kristine
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Medisinske Fakultet
Holmen, Sigve
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Medisinske Fakultet
Onsrud, Mathias
Norway, Oslo
Ouh
Gundersen, Svein Gunnar
Norway, Kristiansand
Sørlandet Hospital
Norway, Kristiansand
Universitetet I Agder
Taylor, Myra
South Africa, Durban
The Nelson R. Mandela Medical School
Kjetland, Eyrun Floerecke
Norway, Oslo
Oslo Universitetssykehus
South Africa, Durban
The Nelson R. Mandela Medical School
Ndung'u, Thumbi P.
South Africa, Durban
The Nelson R. Mandela Medical School
Statistics
Citations: 55
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0098593
e-ISSN:
19326203
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Participants Gender
Female