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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression
Acta Neuropsychiatrica, Volume 30, No. 6, Year 2018
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Description
Objective: This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. Methods: This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers. Results: Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters. Conclusion: The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression. © 2018 Scandinavian College of Neuropsychopharmacology.
Authors & Co-Authors
Panizzutti, B.
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Bortolasci, Chiara Cristina
Brazil, Londrina
Universidade Estadual de Londrina
Australia, Geelong
Deakin University
Kidnapillai, Srisaiyini
Australia, Geelong
Deakin University
Gray, Laura J.
Australia, Geelong
Deakin University
Australia, Melbourne
The Florey
Walder, Ken R.
Australia, Geelong
Deakin University
Berk, Michael
Australia, Geelong
Barwon Health
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Australia, Melbourne
Orygen Youth Health
Dodd, Seetal M.
Australia, Geelong
Barwon Health
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Orygen Youth Health
Gama, Clarissa Severino
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Cotton, Sue M.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
National Centre of Excellence in Youth Mental Health
Kapczinski, Flávio Pereira
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Malhi, Gin Singh
Australia, Sydney
Northern Sydney Local Health District
Australia, Sydney
The University of Sydney
Dean, Olívia May
Australia, Geelong
Barwon Health
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Statistics
Citations: 17
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1017/neu.2018.13
ISSN:
09242708
Research Areas
Cancer
Mental Health