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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identification of common variants associated with human hippocampal and intracranial volumes
Nature Genetics, Volume 44, No. 5, Year 2012
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Description
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10 -16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10 -12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10 -7). © 2012 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Stein, Jason L.
Unknown Affiliation
Medland, Sarah E.
Unknown Affiliation
Vásquez, Alejandro Arias
Unknown Affiliation
Hibar, Derrek Paul
Unknown Affiliation
Senstad, Rudy E.
Unknown Affiliation
Winkler, Anderson M.
Unknown Affiliation
Toro, Roberto
Unknown Affiliation
Appel, Katja
Unknown Affiliation
Bartecek, Richard
Unknown Affiliation
Bergmann, Ørjan
Unknown Affiliation
Bernard, Manon
Unknown Affiliation
Brown, Andrew Anand
Unknown Affiliation
Cannon, Dara M.
Unknown Affiliation
Chakravarty, M. Mallar Mallar
Unknown Affiliation
Christoforou, Andrea Nikie
Unknown Affiliation
Domin, Martin
Unknown Affiliation
Grimm, Oliver
Unknown Affiliation
Hollinshead, Marisa O.
Unknown Affiliation
Holmes, Avram J.
Unknown Affiliation
Homuth, Georg
Unknown Affiliation
Hottenga, Jouke Jan
Unknown Affiliation
Langan, Camilla
Unknown Affiliation
Lopez, Lorna M.
Unknown Affiliation
Hansell, Narelle K.
Unknown Affiliation
Hwang, Kristy S.
Unknown Affiliation
Kim, Sungeun
Unknown Affiliation
Laje, Gonzalo
Unknown Affiliation
Lee, Philhyoun
Unknown Affiliation
Liu, Xinmin
Unknown Affiliation
Loth, Eva
Unknown Affiliation
Lourdusamy, Anbarasu
Unknown Affiliation
Mattingsdal, Morten
Unknown Affiliation
Mohnke, Sebastian
Unknown Affiliation
Muñoz Maniega, Susana
Unknown Affiliation
Nho, Kwangsik
Unknown Affiliation
Nugent, Allison Carol
Unknown Affiliation
O'brien, Carol
Unknown Affiliation
Papmeyer, Martina
Unknown Affiliation
Pütz, Benno
Unknown Affiliation
Ramasamy, Adaikalavan
Unknown Affiliation
Rasmussen, Jerod M.
Unknown Affiliation
Rijpkema, Mark
Unknown Affiliation
Risacher, Shannon Leigh
Unknown Affiliation
Roddey, J. Cooper
Unknown Affiliation
Rose, Emma Jane
Unknown Affiliation
Ryten, Mina
Unknown Affiliation
Shen, Li
Unknown Affiliation
Sprooten, Emma
Unknown Affiliation
Strengman, Eric
Unknown Affiliation
Teumer, Alexander
Unknown Affiliation
Trabzuni, Daniah
Unknown Affiliation
Turner, Jessica A.
Unknown Affiliation
van Eijk, Kristel R.
Unknown Affiliation
van Erp, Theo G.M.
Unknown Affiliation
van Tol, Marie José
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Wittfeld, Katharina
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Wolf, Christiane
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Woudstra, Saskia
Unknown Affiliation
Aleman, André
Unknown Affiliation
Alhusaini, Saud
Unknown Affiliation
Almasy, Laura A.
Unknown Affiliation
Binder, Elisabeth B.
Unknown Affiliation
Brohawn, David G.
Unknown Affiliation
Cantor, Rita M.
Unknown Affiliation
Carless, Melanie A.
Unknown Affiliation
Corvin, Aiden P.
Unknown Affiliation
Czisch, Michael
Unknown Affiliation
Curran, Joanne E.
Unknown Affiliation
Davies, Gail
Unknown Affiliation
De Almeida, Marcio A.A.
Unknown Affiliation
Delanty, Norman
Unknown Affiliation
Depondt, Chantal
Unknown Affiliation
Duggirala, Ravindranath
Unknown Affiliation
Dyer, Thomas D.
Unknown Affiliation
Erk, Susanne
Unknown Affiliation
Fagerness, Jesen A.
Unknown Affiliation
Fox, Peter T.
Unknown Affiliation
Luben, Robert N.
Unknown Affiliation
Gill, Michael J.
Unknown Affiliation
Göring, Harald H.H.
Unknown Affiliation
Hagler, Donald J.
Unknown Affiliation
Hoehn, David
Unknown Affiliation
Holsboer, Florian J.
Unknown Affiliation
Hoogman, Martine
Unknown Affiliation
Hosten, Norbert
Unknown Affiliation
Jahanshad, Neda
Unknown Affiliation
Johnson, Matthew P.
Unknown Affiliation
Kasperavičiũte, Dalia
Unknown Affiliation
Kent, Jack W.
Unknown Affiliation
Kochunov, Peter V.
Unknown Affiliation
Lancaster, Jack L.
Unknown Affiliation
Lawrie, Stephen M.
Unknown Affiliation
Liewald, David C.M.
Unknown Affiliation
Mandl, René Christiaan William
Unknown Affiliation
Matarín, Mar M.
Unknown Affiliation
Mattheisen, M.
Unknown Affiliation
Meisenzahl, Eva Maria
Unknown Affiliation
Melle, Ingrid S.
Unknown Affiliation
Moses, Eric Keith
Unknown Affiliation
Mühleisen, Thomas W.
Unknown Affiliation
Statistics
Citations: 393
Authors: 100
Affiliations: 62
Identifiers
Doi:
10.1038/ng.2250
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Genetics And Genomics
Mental Health