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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Exchange transfusion of a patient with fulminant Lassa fever
Postgraduate Medical Journal, Volume 67, No. 784, Year 1991
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Description
We report a patient with fulminant Lassa fever who responded dramatically to a 2.5-litre exchange transfusion of whole blood. On admission he was semicomatose with facial oedema and oral haemorrhage; his platelets showed markedly depressed aggregation to ADP; and his plasma inhibited the aggregation responses of normal platelets in vitro. Exchange transfusion resulted in rapid clinical improvement, recovery of platelet function, and disappearance of platelet-inhibitory activity in plasma. The patient died 2 weeks later from an acute encephalopathy. His initial response was sufficiently impressive to suggest that further evaluation of this therapeutic approach is justified in selected patients with overwhelming Lassa virus infection. © The Fellowship of Postgraduate Medicine, 1991.
Authors & Co-Authors
Cummins, David
United Kingdom, London
Ucl Medical School
South Africa
Nixon Memorial Hospital and Lassa Fever Research Project
Bennett, Diane E.
South Africa
Nixon Memorial Hospital and Lassa Fever Research Project
MacHin, Samuel J.
United Kingdom, London
Ucl Medical School
Statistics
Citations: 6
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1136/pgmj.67.784.193
ISSN:
00325473
Research Areas
Health System And Policy