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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in the Gambia
Journal of Infectious Diseases, Volume 198, No. 7, Year 2008
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Description
Background. There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and progress to tuberculosis disease. Methods. In a cohort study of patients with tuberculosis and their household contacts in The Gambia, we categorized 1808 HIV-negative tuberculosis contacts according to exposure to M. tuberculosis or M. africanum. Positive skin test results indicated transmission, and development of tuberculosis during 2 years of follow-up indicated progression to disease. Results. Transmission rates were similar, but rates of progression to disease were significantly lower in contacts exposed to M. africanum than in those exposed to M. tuberculosis (1.0% vs. 2.9%; hazard ratio [HR], 3.1 [95% confidence interval {CI}, 1.1-8.7]). Within M. tuberculosis sensu stricto, contacts exposed to a Beijing family strain were most likely to progress to disease (5.6%; HR relative to M. africanum, 6.7 [95% CI, 2.0-22]). Conclusions. M. africanum and M. tuberculosis transmit equally well to household contacts, but contacts exposed to M. africanum are less likely to progress to tuberculosis disease than those exposed to M. tuberculosis. The variable rate of progression by lineage suggests that tuberculosis variability matters in clinical settings and should be accounted for in studies evaluating tuberculosis vaccines and treatment regimens for latent tuberculosis infection. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
De-Jong, Bouke Catherine
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Palo Alto
Stanford University
United States, New York
New York University
Hill, Philip C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Aiken, Alex M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Awine, Timothy
Gambia, Banjul
Medical Research Council Laboratories Gambia
Antonio, Martin
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adetifa, Ifedayo Morayo O.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Jackson-Sillah, Dolly J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
FOX, A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
DeRiemer, Kathryn
United States, Davis
University of California, Davis
Gagneux, Sébastien P.
United States, Seattle
Institute for Systems Biology
Borgdorff, Martien Wilhelm
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, The Hague
Kncv Tuberculosis Foundation
McAdam, Keith P.W.J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Corrah, Tumani P.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Small, Peter M.
United States, Seattle
Institute for Systems Biology
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 287
Authors: 15
Affiliations: 7
Identifiers
Doi:
10.1086/591504
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Gambia