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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Modest reversal of metabolic syndrome manifestations with vitamin D status correction: A 12-month prospective study
Metabolism: Clinical and Experimental, Volume 61, No. 5, Year 2012
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Description
Numerous cross-sectional studies have noted significant negative associations between circulating levels of 25-hydroxyvitamin D and cardiometabolic risk factors, highlighting potential extraskeletal functions of this sterol hormone. Prospective studies, however, have been limited; and hence, no cause-and-effect relations can be inferred. This study aims to determine whether vitamin D status correction can reverse already established manifestations of the metabolic syndrome (MetS). A total of 59 adult nondiabetic, overweight, and obese Saudis (31 male, 28 female) were prospectively enrolled in this 1-year interventional study. Anthropometry and biochemical evaluation were performed, including determination of serum 25-hydroxyvitamin D, calcium, and phosphorous concentrations, as well as fasting blood glucose and lipid profile. Subjects were advised to regularly expose themselves to sunlight and increase intake of vitamin D-rich foods. All measurements were repeated 6 and 12 months later. At the initial baseline visit, the prevalence of both low high-density lipoprotein cholesterol and hypertension was significantly increased among patients with 25-vitamin D deficiency (P <.05), even after adjusting for sex and body mass index. Overall prevalence of MetS patients by the modified National Health and Nutrition Examination Survey Adult Treatment Panel III definition decreased from 25.2% to 13.0%; and this was largely due to a parallel decrease in the prevalence of low high-density lipoprotein cholesterol, triglycerides, and hypertension. Optimization of vitamin D status through sun exposure and increased intake of a vitamin D-rich diet can lead to an improved cardiometabolic profile, offering a promising nonpharmacologic approach in the prevention of MetS manifestations. © 2012 Elsevier Inc.
Authors & Co-Authors
Al-Daghri, N. Mohammad
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Alkharfy, Khalid Mohammad
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Riyadh
College of Pharmacy
al-Saleh, Yousef M.
Saudi Arabia, Riyadh
King Saud University
Al-Attas, Omar Salem
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Alokail, Majed Saleh
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Al-Othman, Abdulaziz M.
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Riyadh
College of Applied Medical Sciences
Moharram, Osama A.
Saudi Arabia, Jeddah
King Abdulaziz University
El-Kholie, Emad M.
Saudi Arabia, Riyadh
King Saud University
Sabico, Shaun
Saudi Arabia, Riyadh
College of Sciences
Kumar, Sudhesh
United Kingdom, Coventry
University of Warwick
Chrousos, George Panagiotis
Saudi Arabia, Riyadh
College of Sciences
Greece, Athens
School of Medicine
Statistics
Citations: 96
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.metabol.2011.09.017
ISSN:
00260495
Research Areas
Food Security
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female