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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
ChAdOx1 nCoV-19 (AZD1222) vaccine candidate significantly reduces SARS-CoV-2 shedding in ferrets
npj Vaccines, Volume 6, No. 1, Article 67, Year 2021
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Description
Vaccines against SARS-CoV-2 are likely to be critical in the management of the ongoing pandemic. A number of candidates are in Phase III human clinical trials, including ChAdOx1 nCoV-19 (AZD1222), a replication-deficient chimpanzee adenovirus-vectored vaccine candidate. In preclinical trials, the efficacy of ChAdOx1 nCoV-19 against SARS-CoV-2 challenge was evaluated in a ferret model of infection. Groups of ferrets received either prime-only or prime-boost administration of ChAdOx1 nCoV-19 via the intramuscular or intranasal route. All ChAdOx1 nCoV-19 administration combinations resulted in significant reductions in viral loads in nasal-wash and oral swab samples. No vaccine-associated adverse events were observed associated with the ChAdOx1 nCoV-19 candidate, with the data from this study suggesting it could be an effective and safe vaccine against COVID-19. Our study also indicates the potential for intranasal administration as a way to further improve the efficacy of this leading vaccine candidate. © 2021, Crown.
Authors & Co-Authors
Marsh, Glenn A.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Riddell, Sarah Jane
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Singanallur, Nagendrakumar Balasubramanian
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Durr, P. A.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Barr, Jennifer A.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Bingham, John
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Holmes, Clare E.G.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Jansen Van Vuren, Petrus
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Tachedjian, Mary
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Todd, Shawn
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Drew, Trevor W.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Gilbert, Sarah C.
United Kingdom, Oxford
The Jenner Institute
Lambe, Teresa
United Kingdom, Oxford
The Jenner Institute
Vasan, Seshadri S.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
United Kingdom, York
University of York
Statistics
Citations: 27
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.1038/s41541-021-00315-6
ISSN:
20590105
Research Areas
Covid
Health System And Policy