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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High treatment uptake in human immunodeficiency virus/ hepatitis C virus-coinfected patients after unrestricted access to direct-acting antivirals in the Netherlands
Clinical Infectious Diseases, Volume 66, No. 9, Year 2018
Notification
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Description
The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide hepatitis C virus (HCV) treatment uptake among patients coinfected with human immunodeficiency virus (HIV) and HCV. Methods. Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA result, did not have spontaneous clearance, and were known to still be in care. Treatment uptake and outcome were assessed. When patients were treated more than once, data were included from only the most recent treatment episode. Data were updated until February 2017. In addition, each treatment center was queried in April 2017 for a data update on DAA treatment and achieved sustained virological response. Results. Of 23 574 HIV-infected patients ever linked to care, 1471 HCV-coinfected patients (69% men who have sex with men, 15% persons who [formerly] injected drugs, and 15% with another HIV transmission route) fulfilled the inclusion criteria. Of these, 87% (1284 of 1471) had ever initiated HCV treatment between 2000 and 2017, 76% (1124 of 1471) had their HCV infection cured; DAA treatment results were pending in 6% (92 of 1471). Among men who have sex with men, 83% (844 of 1022) had their HCV infection cured, and DAA treatment results were pending in 6% (66 of 1022). Overall, 187 patients had never initiated treatment, DAAs had failed in 14, and a pegylated interferon-alfa-based regimen had failed in 54. Conclusions. Fifteen months after unrestricted DAA availability the majority of HIV/HCV-coinfected patients in the Netherlands have their HCV infection cured (76%) or are awaiting DAA treatment results (6%). This rapid treatment scale-up may contribute to future HCV elimination among these patients. © The Author(s) 2017.
Authors & Co-Authors
Smit, Colette
Netherlands, Amsterdam
Stichting Hiv Monitoring
Arends, Joop E.A.
Netherlands, Utrecht
University Medical Center Utrecht
Richter, Clemens
Netherlands, Arnhem
Rijnstate Hospital
Reiss, Peter
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Amsterdam
Stichting Hiv Monitoring
Netherlands, Amsterdam
Amsterdam Institute for Global Health and Development
Rijnders, Bart J.A.
Netherlands, Rotterdam
Erasmus Mc
Brinkman, Kees
Netherlands, Amsterdam
Olvg
van der Valk, Marc
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Geerlings, Suzanne Eugenie
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Goorhuis, Abram
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Hovius, Joppe Willem R.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Meer, Jan T.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Kuijpers, T. W.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Prins, Jan M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wiersinga, Willem Joost
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wit, Ferdinand W.N.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Jurriaans, Suzanne
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Back, Nicole K.T.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Zaaijer, Hans L.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Berkhout, Ben
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Cornelissen, Marion T.E.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wolthers, Katja C.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Stegeman, Jan Arend
Unknown Affiliation
Veenemans, Jacobien
Unknown Affiliation
Ammerlaan, Heidi S.M.
Netherlands, Eindhoven
Catharina Ziekenhuis
Brouwer, Annemarie E.
Unknown Affiliation
van der Ende, Marchina Elisabeth
Netherlands, Rotterdam
Erasmus Mc
van Gorp, E. C.
Netherlands, Rotterdam
Erasmus Mc
Nouwen, Jan L.
Netherlands, Rotterdam
Erasmus Mc
Verbon, Annelies
Netherlands, Rotterdam
Erasmus Mc
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Koopmans, Marion P.G.
Netherlands, Rotterdam
Erasmus Mc
Pas, Suzan D.
Netherlands, Rotterdam
Erasmus Mc
van Nieuwkoop, Cees
Netherlands, The Hague
Hagaziekenhuis
Leyten, Eliane Madeleine Sophie
Netherlands, Leidschendam
Hmc
Kroon, Frank P.
Netherlands, Leiden
Leids Universitair Medisch Centrum
de Boer, Mark G.J.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Vollaard, Albert M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Claas, Eric C.J.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Wessels, Els
Netherlands, Leiden
Leids Universitair Medisch Centrum
den Hollander, Jan G.
Netherlands, Rotterdam
Maasstad Ziekenhuis
Smit, Erasmus J.
Netherlands, Rotterdam
Maasstad Ziekenhuis
Pontesilli, Oscar
Netherlands, Rotterdam
Maasstad Ziekenhuis
Oude Lashof, Astrid M.L.
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
van Loo, Inge H.M.
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Mulder, Jan Willem A.
Unknown Affiliation
van Vonderen, Marit G.A.
Netherlands, Leeuwarden
Medisch Centrum Leeuwarden
Kampschreur, Linda Martine
Netherlands, Leeuwarden
Medisch Centrum Leeuwarden
Delsing, Corine E.
Netherlands, Enschede
Medisch Spectrum Twente Mst
van Crevel, Reinout
Netherlands, Nijmegen
Radboud University Medical Center
Keuter, Monique M.
Netherlands, Nijmegen
Radboud University Medical Center
van der Ven, André J.A.M.
Netherlands, Nijmegen
Radboud University Medical Center
ter Hofstede, Hadewych J.M.T.
Netherlands, Nijmegen
Radboud University Medical Center
Hoogerwerf, Jacobien J.
Netherlands, Nijmegen
Radboud University Medical Center
Rahamat-Langendoen, Janette C.
Netherlands, Nijmegen
Radboud University Medical Center
Stelma, Foekje F.
Netherlands, Nijmegen
Radboud University Medical Center
Burger, David Marinus
Netherlands, Nijmegen
Radboud University Medical Center
Soetekouw, Robert
Unknown Affiliation
Jansen, Ruud R.
Unknown Affiliation
Bakker, Margreet E.G.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Kleinnijenhuis, Johanneke
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Stienstra, Ymkje
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Boonstra, André
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Niesters, Hubert G.M.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Hoepelman, Andy I.M.
Netherlands, Utrecht
University Medical Center Utrecht
Barth, Roos E.
Netherlands, Utrecht
University Medical Center Utrecht
Mudrikova, Tania
Netherlands, Utrecht
University Medical Center Utrecht
Wassenberg, Marjan W.M.
Netherlands, Utrecht
University Medical Center Utrecht
Schuurman, Rob J.
Netherlands, Utrecht
University Medical Center Utrecht
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Peters, Edgar J.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Van Agtmael, Michiel A.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Van Houdt, Robin
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Pettersson, Annika M.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Vandenbroucke- Grauls, Christina Maria Joseph Elisabeth
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Bezemer, Daniela O.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
van Sighem, Ard I.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Boender, T. Sonia
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Hillebregt, Mariska M.J.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
de Groot, Laura
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Statistics
Citations: 55
Authors: 79
Affiliations: 20
Identifiers
Doi:
10.1093/cid/cix1004
ISSN:
10584838
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Male